Glycyrrhizae radix syrup

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT LICORICE ROOT SYRUP

Composition:

Active substance: 5 ml of syrup contains 0.25 g of concentrated extract of licorice root (Liquiritiae radix) (2.75–3:1) (extractant – water);

Excipients: confectionery sugar, 90% ethanol, purified water.

Pharmaceutical form. Syrup.

Main physicochemical properties: viscous brown liquid with a characteristic odor. Sedimentation may occur during storage.

Pharmacotherapeutic group.

Medicinal products used for cough and colds. Expectorants. ATC code R05C A.

Pharmacological Properties

Pharmacodynamics

The roots of Glycyrrhiza glabra contain glycyrrhizin, potassium and calcium salts of glycyrrhizic acid, and flavonoid glycosides (liquiritin, liquiritigenin, liquiritoside). The expectorant effect of licorice preparations is associated with glycyrrhizin content, which stimulates the activity of the ciliated epithelium of the trachea and bronchi and enhances the secretory function of the mucous membranes of the upper respiratory tract.

The spasmolytic effect of the drug on smooth muscles of the respiratory tract is due to the presence of flavonoid compounds, among which liquiritoside is the most active. The anti-inflammatory (corticosteroid-like) effect is attributed to glycyrrhizic acid, released upon hydrolysis of glycyrrhizin.

Pharmacokinetics. Not studied.

Clinical characteristics.

Indications.

Used in the complex therapy of infectious and inflammatory diseases of the respiratory tract accompanied by difficult expectoration and cough (acute and chronic bronchitis, tracheobronchitis, pneumonia, bronchiectasis).

As an adjunctive agent in chronic hyperacid gastritis.

Contraindications.

Hypersensitivity to the components of the drug. Diabetes mellitus, liver and kidney dysfunction, arterial hypertension, hypokalemia, severe obesity.

Interaction with other medicinal products and other forms of interaction.

Hypokalemia (due to excessive use of licorice root) may be intensified when used concomitantly with cardiac glycosides, antiarrhythmic agents, and drugs affecting cardiac rhythm (e.g., quinidine). When used in combination with drugs that may cause hypokalemia (thiazide and loop diuretics, adrenocorticosteroids, and laxatives), electrolyte imbalance may occur; therefore, prolonged simultaneous use of "Licorice Root Syrup" with the above-mentioned medicinal products should be avoided.

When taking any other medicinal products concurrently, inform your physician.

Special precautions for use.

The syrup contains sugar, therefore it should not be used in patients with diabetes mellitus.

Alcohol content in 1 ml – not less than 5%. The medicinal product is not recommended for prolonged use, as it may lead to disturbances in water-salt metabolism and edema.

Use during pregnancy or breastfeeding.

The drug is contraindicated during pregnancy, since licorice root increases estrogen levels, thereby disrupting hormonal balance. It stimulates uterine activity. In high doses, it exerts embryotoxic effects.

If it is necessary to take the drug during treatment, breastfeeding should be discontinued.

Ability to affect reaction rate when driving or operating machinery.

During the use of this drug, patients should refrain from driving vehicles or operating potentially hazardous machinery.

Method of Administration and Dosage.

For adults and children aged 12 years and older, administer 1 tablespoon (15 ml) of syrup after meals 3–4 times daily.

The duration of treatment is determined individually by a physician for each patient, depending on the severity and specific characteristics of the disease, stability of the achieved therapeutic effect, and the drug's tolerability.

Children.

The medication should not be prescribed to children under 12 years of age.

Overdose.

In case of overdose, an intensification of adverse reactions may occur.

Side effects.

In individual cases, allergic reactions are possible, including skin redness, rash, itching, swelling; water-electrolyte imbalance (appearance of edema), increased blood pressure. Prolonged use of licorice preparations in excessive doses may lead to the development of hypokalemia; in individual cases, hypokalemic myopathy and myoglobinuria are possible.

If any adverse reactions occur, discontinue use of the product immediately and consult a physician!

Shelf life.

2 years.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 °C. After opening the bottle, store for no more than 14 days at a temperature between 8 °C and 15 °C.

Keep out of reach of children.

Packaging.

50 g in a glass or polymer bottle with a measuring spoon in a carton.

100 g in a polymer jar with a measuring spoon in a carton.

100 g in a polymer bottle with a measuring spoon in a carton.

Dispensing category.

Over-the-counter.

Manufacturer/Marketing authorization holder.

LLC "Ternopharm".

Manufacturer's address and location of its business activity / Holder's address.

Ukraine, 46010, Ternopil, Fabrychna St., 4.

Tel./fax: (0352) 521-444, www.ternopharm.com.ua.