Izotek 10 mg: detailed information

Package leaflet: Information for the user

Warning! Keep this leaflet, information on the outer packaging in a foreign language!
Izotek 10 mg (A-CNOTREN)
10 mg, soft capsules
Isotretinoinum
Izotek 10 mg and A-CNOTREN are different brand names of the same medicine.
WARNING
CAN CAUSE SEVERE HARM TO AN UNBORN CHILD
Women must use effective contraception methods.
Do not use during pregnancy or if pregnancy is suspected.
This medicinal product will be subject to additional monitoring. This will allow for rapid
identification of new safety information. You, as a user of this medicine, can also help by
reporting any adverse reactions that occur after using the medicine. For information on how to
report adverse reactions – see the last paragraph of section 4.
Please read this leaflet carefully before taking this medicine, as it contains
important information for the patient.

Keep this leaflet, as you may need to read it again.
If you have any questions, please consult your doctor or pharmacist.
This medicine has been prescribed for a specific individual. Do not pass it on to others. The medicine may harm another person, even if their symptoms are the same.
If you experience any adverse effects, including any not listed in this leaflet, inform your doctor or pharmacist. See section 4.

Contents of the leaflet

What Izotek 10 mg is and what it is used for
Important information before taking Izotek 10 mg
How to take Izotek 10 mg
Possible adverse reactions
How to store Izotek 10 mg
Contents of the pack and other information

1. What Izotek 10 mg is and what it is used for

Izotek 10 mg contains the active substance isotretinoin – a substance related to vitamin A and
belonging to a group of medicines known as retinoids (used in the treatment of acne).
Izotek 10 mg is used to treat severe forms of acne (such as nodular or conglobate acne, or acne with a risk of permanent scarring) in adults and adolescents over the age of 12, only after puberty has begun.
Izotek 10 mg will be used only if the severity of acne has not been reduced by treatment with other anti-acne medicines, including antibiotics and topical treatments.
Treatment with Izotek 10 mg must be supervised by a dermatologist (a doctor specializing in skin disease treatment).

2. Important information before using Izotek 10 mg

When not to use Izotek 10 mg:

if the patient is allergic to isotretinoin, peanuts or soy, or to any of the other ingredients of this medicine (listed in section 6),
if the patient is pregnant or breastfeeding,
if there is any risk that the patient could become pregnant, it is necessary to follow the precautions outlined in the Pregnancy Prevention Programme, see section “Warnings and precautions”,
in women who could become pregnant but are unable or unwilling to comply with the necessary pregnancy prevention measures specified in the Pregnancy Prevention Programme for Izotek 10 mg,
in liver disease,
in patients with very high levels of lipids in the blood (e.g. high cholesterol or triglyceride levels),
in patients with very high levels of vitamin A in the body (hypervitaminosis A),
during concomitant treatment with tetracyclines (an antibiotic used, among others, in the treatment of acne) (see “Other medicines and Izotek 10 mg”).

If any of the above situations apply, you should consult your doctor before starting to take Izotek 10 mg.
Warnings and precautions
Before starting to take Izotek 10 mg, discuss this with your doctor or pharmacist.
Pregnancy Prevention Programme
IMPORTANT
Information for women
Women who are pregnant must not take Izotek 10 mg.
This medicine may severely harm the unborn child (the medicine has a "teratogenic" effect). It may
cause severe malformations of the brain, face, ears, eyes, heart and certain glands
(thymus and parathyroid glands) of the foetus. It also increases the risk of miscarriage. These effects
may occur even if Izotek 10 mg is taken for only a short time during pregnancy.

Do not take Izotek 10 mg if you are pregnant or suspect you may be pregnant.
Do not take Izotek 10 mg during breastfeeding. The medicine is likely to pass into breast milk and may harm the nursing infant.
Do not take Izotek 10 mg if you could become pregnant during treatment.
You must not become pregnant for one month after stopping treatment, as the medicine may still be present in your body.

Izotek 10 mg may be prescribed to women capable of becoming pregnant only if strict adherence
to specific requirements is ensured. This is due to the risk of severe birth defects in the unborn child.
The following conditions must be met:

The doctor must explain to the patient the risk of harm to the unborn child (birth defects); the patient must understand why she must not become pregnant and how to prevent it.
The patient must discuss contraception (birth control methods) with the doctor. The doctor will provide information on contraceptive methods. The doctor may refer the patient to a specialist for contraceptive advice.
Before starting treatment, the doctor will ask the patient to take a pregnancy test. The test must confirm that the patient is not pregnant at the start of treatment with Izotek 10 mg.

Women must use effective contraceptive methods before, during and after treatment with
Izotek 10 mg.

The patient must agree to use at least one highly reliable method of contraception (such as an intrauterine device or contraceptive implant), or two effective methods acting in different ways (e.g. oral hormonal contraceptives and condoms). Discuss with your doctor which methods are most suitable for you.
The patient must use contraception for one month before starting Izotek 10 mg, during treatment, and for one month after stopping the medicine.
The patient must use contraception even if she is not menstruating or is not currently sexually active (unless the doctor determines it is not necessary).

Women must agree to undergo pregnancy tests before, during and after
treatment with Izotek 10 mg.

The patient must agree to attend regular check-ups with the doctor, ideally every month.
The patient must agree to undergo regular pregnancy tests, ideally every month during treatment and one month after stopping treatment with Izotek 10 mg, as the medicine may still be present in the body (unless the doctor decides it is not necessary for a particular patient).
The patient must agree to undergo additional pregnancy tests as recommended by the treating doctor.
The patient must not become pregnant during or within one month after stopping treatment, as the medicine may still be present in her body.
The treating doctor will discuss all issues with the patient using a checklist and will ask the patient (or her parent or legal guardian) to sign it. This form confirms that the patient has been informed of the risks and agrees to follow the rules outlined above.

If a woman becomes pregnant while taking Izotek 10 mg, she must immediately
stop taking the medicine and contact her doctor. The doctor may refer her to a specialist for advice.
Furthermore, a woman who becomes pregnant within one month after stopping
treatment with Izotek 10 mg should contact her treating doctor. The doctor may
refer her to a specialist for advice.
Advice for men
The amount of oral retinoids in the semen of men taking Izotek 10 mg is too low to harm the unborn child of their partner. However, this medicinal product must never be shared with anyone else, especially women.
Additional precautions
Never pass this medicinal product on to another person. All unused capsules must be returned to the pharmacist after treatment is completed.
You must not donate blood while taking this medicine or within one month after
stopping Izotek 10 mg. If a pregnant woman receives your blood, she may give birth to a child with congenital malformations.
Information for all patients

Discuss with your doctor if you have ever had any mental health problems, including depression, aggressive tendencies or mood swings. This is because Izotek 10 mg may affect your mood. You may not notice certain changes in your mood or behaviour, so it is very important to inform your friends and family members that you are taking this medicine. They may notice such changes and help you quickly identify any problems that need to be discussed with your doctor.
Severe skin reactions (e.g. erythema multiforme [EM], Stevens-Johnson syndrome [SJS], or toxic epidermal necrolysis [TEN]) have been observed during isotretinoin treatment. Skin rash may present as widespread blistering or peeling of the skin. Also watch for ulcers in the mouth, throat, nose and genital organs, as well as conjunctivitis (redness and swelling of the eyes).
In rare cases, Izotek 10 mg may cause severe allergic reactions, which may include skin rash, hives, bruising or red spots on the hands and feet. If an allergic reaction occurs, stop taking Izotek 10 mg immediately, contact your doctor without delay and inform them that you are taking this medicine.
Limit intense physical exertion and exercise. Izotek 10 mg may cause muscle and joint pain, particularly in children and adolescents who engage in intense physical activity.
Isotretinoin use has been associated with idiopathic inflammatory bowel disease. If a patient without a history of gastrointestinal disorders develops severe bloody diarrhoea, the doctor will discontinue treatment with Izotek 10 mg.
Izotek 10 mg may cause dry eye syndrome, intolerance to contact lenses and vision problems, including night vision impairment. Inform your doctor if any of these symptoms occur. Your doctor may recommend using moisturising eye ointments or artificial tears. If contact lenses are not tolerated, your doctor may recommend wearing glasses during treatment. If vision problems occur, your doctor may refer you to a specialist for advice and may also recommend stopping Izotek 10 mg.
Mild intracranial hypertension has been observed during isotretinoin treatment, in some cases while also taking tetracyclines (a type of antibiotic used, for example, in acne treatment). If symptoms such as headache, nausea, vomiting or visual disturbances occur, stop taking Izotek 10 mg immediately and contact your doctor without delay. The doctor may refer you to a specialist to check for papilloedema (swelling of the optic disc in the eye).
Izotek 10 mg may increase liver enzyme activity. Your treating doctor will order appropriate blood tests before, during and after treatment to monitor liver enzyme activity. If enzyme activity remains elevated, your doctor may reduce the dose or discontinue treatment with Izotek 10 mg.
Isotretinoin often leads to increased blood lipid levels, such as cholesterol or triglycerides. Your doctor will check lipid levels before starting treatment with Izotek 10 mg, during treatment and after it ends. During treatment, it is best to avoid alcoholic beverages or at least reduce their consumption. Inform your doctor if you have high blood lipid levels, diabetes (high blood glucose levels), or if you are overweight or suffer from alcoholism. More frequent blood tests may be necessary. If blood lipid levels remain high, your doctor may reduce the dose or discontinue treatment with Izotek 10 mg.
Inform your doctor if you have any kidney problems. Your doctor may start treatment with a lower dose of Izotek 10 mg and then increase it to the maximum tolerated dose.
Izotek 10 mg may lead to increased blood glucose levels. In rare cases, diabetes has developed in patients. Your doctor may monitor blood glucose levels during treatment, especially if you already have diabetes or are overweight or suffer from alcoholism.
Skin dryness is likely to occur. During treatment, use a moisturising cream or ointment and lip balm. To prevent skin irritation, avoid using peeling or anti-acne products.
Avoid excessive sun exposure and do not use sunlamps or tanning beds. The skin may become more sensitive to sunlight. Before going out in the sun, apply a sunscreen product with a high sun protection factor (SPF of at least 15).
Do not undergo any cosmetic skin procedures. Izotek 10 mg may make the skin more sensitive. Do not use wax for hair removal, dermabrasion or laser treatments (to remove keratinised skin or scars) during treatment and for at least 6 months after treatment ends, as this may lead to scarring, skin irritation or, in rare cases, skin discoloration.

Children and adolescents
Izotek 10 mg is not recommended for children under 12 years of age. It is not known whether the medicine is safe or effective in this age group.
Use in adolescents over 12 years of age is only possible after puberty.
Other medicines and Izotek 10 mg
Tell your doctor or pharmacist about all medicines you are currently taking or have recently taken, as well as any medicines you plan to take, including those available without a prescription.

While taking Izotek 10 mg, do not take vitamin A supplements or tetracyclines (an antibiotic used, for example, in acne treatment), or apply any topical anti-acne products to the skin. You may use moisturisers and emollients (creams or skin products that prevent water loss and soften the skin).
While taking Izotek 10 mg, avoid topical use of keratolytic or exfoliating anti-acne products.

Pregnancy and breastfeeding
If you are pregnant or breastfeeding, suspect you may be pregnant, or plan to have a child, consult your doctor before using this medicine.
Pregnancy
Izotek 10 mg must not be used during pregnancy. If you are capable of becoming pregnant, you must use an effective method of contraception during treatment with Izotek 10 mg and for one month after stopping the medicine.
If you become pregnant while taking Izotek 10 mg or within one month after stopping treatment, stop taking the medicine immediately and contact your doctor. The doctor may refer you to a specialist for advice.
Taking Izotek 10 mg during pregnancy may harm the foetus (as the medicine has a teratogenic effect). It also increases the risk of miscarriage.
Izotek 10 mg may cause serious abnormalities in the brain, face, ears, eyes, heart and certain glands (thymus and parathyroid glands) of the foetus.
Breastfeeding
Do not take Izotek 10 mg while breastfeeding. This medicine is likely to pass into breast milk and may harm the nursing infant.
More information on pregnancy and contraception can be found in section 2 “Pregnancy Prevention Programme”.
Driving and operating machinery
During treatment, night vision may be impaired. These visual disturbances may occur suddenly. In rare cases, they persist after treatment ends. Very rarely, drowsiness, dizziness and visual disturbances have been reported. If any of these symptoms occur, the patient must not drive or operate machinery.
Izotek 10 mg contains soya oil. Do not take Izotek 10 mg if you are allergic to peanuts or soya.

3. How to use the medicine Izotek 10 mg

This medicine should always be taken exactly as prescribed by your doctor. If in doubt, consult your doctor or pharmacist.
The medicine Izotek 10 mg and the medicine Izotek 20 mg are available on the market.
Recommended dose:
The initial dose is usually 0.5 mg per kilogram of body weight per day (0.5 mg/kg bw/day).
If the patient's weight is 60 kg, treatment is usually started at a dose of 30 mg per day.
Capsules should be taken once or twice daily.
The medicine should be taken with a full stomach. Capsules must be swallowed whole, taken with food or immediately after a meal.
After several weeks, your doctor may adjust the dose. This depends on how well the patient tolerates the treatment and on the therapeutic response. For most patients, the dose ranges from 0.5 mg/kg bw/day to 1 mg/kg bw/day. If the patient feels that the effect of Izotek 10 mg is too weak or too strong, this should be reported to the doctor or pharmacist.
Treatment usually lasts from 16 to 24 weeks. For most patients, only one treatment cycle is required. Acne symptoms may continue to improve for up to 8 weeks after completion of treatment. Usually, a new treatment cycle is not started within this period.
Some individuals may experience a temporary worsening of acne during the first weeks of treatment. These symptoms usually improve as treatment continues.
Patients with impaired kidney function
In cases of severe kidney disease, treatment should be initiated at a lower dose (e.g., 10 mg/day), which may then be gradually increased to the maximum dose tolerated by the patient.
If the patient cannot tolerate the recommended dose, a lower dose may be administered, which may result in a longer treatment duration and a higher likelihood of acne recurrence.
Taking more than the recommended dose of Izotek 10 mg
If a patient takes too many capsules or if someone else accidentally ingests this medicine, contact a doctor, pharmacist, or the nearest hospital immediately.
Isotretinoin is a derivative of vitamin A. Symptoms of poisoning with Izotek 10 mg are similar to those of vitamin A toxicity, such as headache, nausea, vomiting, dizziness, irritability, and itching.
Missed dose of Izotek 10 mg
If a dose is missed, take it as soon as possible. However, if it is almost time for the next dose, do not take the missed dose. Continue treatment according to the prescribed schedule. Do not take a double dose to make up for a missed dose.
If you have any further questions about the use of this medicine, consult your doctor or pharmacist.

4. Possible adverse effects

Like any medicine, this medicine can cause adverse effects, although they do not occur in everyone.
These symptoms often diminish or resolve after discontinuation of treatment. Others may be severe and
require immediate medical attention.
Adverse effects requiring immediate medical assistance:
Skin problems
Frequency unknown (frequency that cannot be estimated from available data)

Severe skin rashes (erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis), which may be life-threatening and require immediate medical assistance. Initially, they appear as circular spots, often with central blisters, usually located on hands and palms or feet and soles. More severe rashes may involve blister formation on the chest and back. Additional symptoms may also occur, such as eye infection (conjunctivitis) or ulcers in the mouth, throat, or nose. Some types of rashes may progress to extensive skin peeling, which may be life-threatening. The onset of these severe skin rashes is often preceded by headache, fever, and body aches (flu-like symptoms).

If the patient develops a severe rash or the skin symptoms described above, stop taking
Izotek 10 mg immediately and contact a doctor without delay.
Psychiatric disorders
Rare adverse effects (may occur in less than 1 in 1,000 patients)

Depression or related disorders. Symptoms include sadness, mood changes, anxiety, and feelings of emotional discomfort.
Worsening of existing depression.
Tendency towards violence or aggression.

Very rare adverse effects (may occur in less than 1 in 10,000 patients)

Some individuals experienced thoughts or images of self-harm or suicide (suicidal thoughts), attempted suicide, or died by suicide. These individuals did not necessarily show symptoms of depression.
Unusual behaviour.
Psychotic symptoms: loss of contact with reality, e.g. the patient hears voices or sees things that do not exist in reality.

If any of the psychiatric symptoms described above occur, contact a doctor immediately.
The doctor may recommend discontinuation of Izotek 10 mg. Stopping the medicine may not be sufficient for these effects to resolve; additional help may be required, which the doctor can provide.
Allergic reactions
Rare adverse effects (may occur in less than 1 in 1,000 patients)

Severe (anaphylactic) reactions: breathing or swallowing difficulties due to sudden swelling of the throat, face, lips, and oral cavity. Also, sudden swelling of hands, feet, and ankles.

Very rare adverse effects (may occur in less than 1 in 10,000 patients)

Sudden chest tightness, shortness of breath, and wheezing, especially if the patient suffers from asthma.

In case of a severe reaction, go immediately to an emergency department.
If any allergic reaction occurs, stop taking Izotek 10 mg and contact your doctor.
Musculoskeletal system
Frequency unknown (frequency that cannot be estimated from available data)

Muscle weakness, which may potentially be life-threatening, may be associated with difficulties moving arms or legs, pain, swelling, discolouration of body parts, dark urine, reduced urine output or cessation of urine production, confusion, or dehydration. These are symptoms of rhabdomyolysis, i.e. breakdown of muscle tissue, which may lead to kidney failure. This may occur during intense physical activity while taking Izotek 10 mg.

Liver and kidney function disorders
Very rare adverse effects (may occur in less than 1 in 10,000 patients)

Yellowing of the skin or whites of the eyes and feeling tired. These may be symptoms of hepatitis. Stop taking Izotek 10 mg immediately and contact a doctor.
Problems with urination, swollen and puffy eyelids, feeling extremely tired. These may be symptoms of kidney inflammation. Stop taking Izotek 10 mg immediately and contact a doctor.

Nervous system disorders
Very rare adverse effects (may occur in less than 1 in 10,000 patients)

Persistent headache accompanied by nausea, vomiting, and vision disturbances, including blurred vision. These may be symptoms of benign intracranial hypertension, particularly when Izotek 10 mg is taken concomitantly with tetracycline antibiotics. Stop taking Izotek 10 mg immediately and contact your doctor.

Gastrointestinal disorders
Very rare adverse effects (may occur in less than 1 in 10,000 patients)

Severe abdominal pain with bloody diarrhoea, nausea and vomiting, or without these symptoms. These may be symptoms of severe intestinal diseases.

Stop taking Izotek 10 mg immediately and contact your doctor.
Eye disorders
Very rare adverse effects (may occur in less than 1 in 10,000 patients)

Blurred vision.

If blurred vision occurs, stop taking Izotek 10 mg immediately and contact a doctor.
If any other changes in vision occur, contact a doctor as soon as possible.
Other adverse effects
Very common adverse effects (may occur in more than 1 in 10 patients)

Dry skin, especially around the lips and face, skin inflammation, chapped and inflamed lips, rash, mild itching, and slight peeling. A moisturising cream should be used from the beginning of treatment.
Skin more sensitive and redder than usual, especially on the face.
Back pain, muscle pain, joint pain, particularly in children and adolescents. To avoid worsening any musculoskeletal or joint symptoms, reduce intense physical activity during treatment with Izotek 10 mg.
Eye inflammation (conjunctivitis) and eyelids, dryness and irritation of the eyes. Consult a pharmacist for appropriate eye drops. In case of dry eye syndrome, wearing glasses instead of contact lenses may be necessary.
Increased liver enzyme activity in blood tests.
Altered blood lipid levels (including HDL or triglycerides).
Bruising, bleeding, or faster blood clotting – if the problem involves cells responsible for blood clotting.
Anaemia – weakness, dizziness, pale skin – if the problem involves red blood cells.

Common adverse effects (may occur in less than 1 in 10 patients)

Headache.
Higher blood cholesterol levels.
Presence of protein or blood in urine.
Increased susceptibility to infections, if the problem involves white blood cells.
Drying of the nasal cavity and formation of crusts leading to mild nosebleeds.
Pain or inflammation in the throat and nasal cavity.
Allergic reactions such as rash, itching. If any allergic reaction occurs, stop taking Izotek 10 mg and contact a doctor.

Rare adverse effects (may occur in less than 1 in 1,000 patients)

Hair loss (alopecia). Usually temporary. It should resolve after completion of treatment.

Very rare adverse effects (may occur in less than 1 in 10,000 patients)

May lead to worsening night vision, colour blindness, and poorer colour perception.
May lead to increased light sensitivity; wearing sunglasses may be necessary to protect eyes from bright light.
Other vision problems, including blurred vision, image distortion, clouding of the eye surface (corneal clouding, cataract).
Excessive thirst, frequent urination, blood test results indicating increased blood glucose levels. These may be symptoms of diabetes.
Acne may worsen during the first few weeks, but symptoms should gradually improve over time.
Skin inflamed, swollen, and darker than usual, especially on the face.
Excessive sweating or itching.
Joint inflammation; problems with the skeletal system (growth delay, excessive growth, and changes in bone density); may lead to inhibition of growth in growing bones.
Calcium deposition in soft tissues, tendon pain, and high levels of muscle breakdown products in blood during intense physical activity.
Increased light sensitivity.
Bacterial infections at the base of nails, nail changes.
Swelling, discharge, pus.
Excessive scarring after surgery.
Increased body hair growth.
Seizures, drowsiness, dizziness.
May lead to swelling of lymph nodes.
Dry throat, hoarseness.
Hearing problems.
General malaise.
High blood uric acid levels.
Bacterial infections.
Vasculitis (sometimes with bruising, red spots).

Frequency unknown (frequency that cannot be estimated from available data)

Dark or dark brown urine.
Difficulty achieving or maintaining erection.
Reduced sexual drive.
Breast swelling with or without tenderness, occurring in men.
Vaginal dryness.

Reporting of adverse effects
If any adverse effects occur, including any not listed in this leaflet, inform your doctor or pharmacist. Adverse effects can be reported directly to the Department of Monitoring of Adverse Drug Reactions of the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products, al. Jerozolimskie 181C, 02-222 Warsaw, tel.: +48 22 49 21 301, fax: +48 22 49 21 309, Website: https://smz.ezdrowie.gov.pl
Reporting adverse effects helps to provide more information on the safety of the medicine.

5. How to store Izotek 10 mg

Keep this medicine out of sight and reach of children.
Do not store above 30°C. Store in the original packaging.
Keep the container tightly closed to protect from light.
Do not use this medicine after the expiry date stated on the packaging after: EXP.
The expiry date refers to the last day of the stated month.
Any unused capsules should be returned to the pharmacist. Only keep them if your
doctor advises you to do so.
Medicines must not be disposed of via wastewater or household waste. Ask
your pharmacist how to dispose of medicines no longer required. These measures will help
protect the environment.

6. Contents of the pack and other information

What Izotek 10 mg contains

The active substance is isotretinoin. Each soft capsule contains 10 mg of isotretinoin.
The other ingredients are: purified soybean oil, yellow wax, hydrogenated soybean oil, partially hydrogenated soybean oil, capsule shell: gelatin, glycerol, titanium dioxide (E 171), red iron oxide (E 172), yellow iron oxide (E 172).

What Izotek 10 mg looks like and contents of the pack
Izotek 10 mg are red-orange oval capsules (size 3).
The medicine is available in cardboard boxes containing PVC/PE/PVDC/Aluminium blisters.
Pack size available: 100 soft capsules.
For more detailed information, please contact the responsible party or parallel importer.

Marketing Authorisation Holder in Greece, country of export:
Pharmathen Investments Group Limited
Kritis 32, Papachristoforou Building, 4 floor
3087 Lemesos, Cyprus

Manufacturer:
Pharmathen S.A.
6, Dervenakion Str.
153 51 Pallini
Athens, Greece
Pharmathen International S.A.
Industrial Park Sapes, Block No 5
Rodopi Prefecture 69300, Greece

Parallel Importer:
ProCarePlus Pharma S.A.
ul. Bobrzyńskiego 14, 30-348 Kraków

Repackaged in:
CanPoland S.A.
ul. Beskidzka 190, 91-610 Łódź
Chemiczno-Farmaceutyczna Spółdzielnia Pracy "ESPEFA"
ul. Juliusza Lea 208, 30-133 Kraków

Marketing Authorisation number in Greece, country of export: 45/16-01-2012
Parallel Import Licence Number: 37/22
This medicinal product is authorised in the Member States of the European Economic Area under the following names:
Denmark: Isotretinoin Orion
Finland: Isotretinoin Orion
Poland: Izotek
Greece: A-Cnotren 10 mg

Detailed and up-to-date information about this medicinal product is available by scanning with a smartphone the QR code located in the package leaflet. The same information is also available on the website:
https://pcp-izotek.pl/
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