Fiasp 100 units/ml FlexTouch solution for injection in pre-filled pen

Package leaflet: Information for the user

Introduction

Package leaflet: information for the patient

Fiasp 100 units/ml FlexTouch pre-filled pen solution for injection

insulin aspart

Read all of this leaflet carefully before you start using this medicine, because it contains important information for you.

• Keep this leaflet as you may need to read it again.
• If you have any questions, ask your doctor, pharmacist or nurse.
• This medicine has been prescribed for you only and must not be given to other people, even if they have the same symptoms as you, because it may harm them.
• If you experience any side effects, talk to your doctor, pharmacist or nurse, even if they are not listed in this leaflet. See section 4.

What is in this leaflet

1. What Fiasp is and what it is used for
2. What you need to know before using Fiasp
3. How to use Fiasp
4. Possible side effects
5. How to store Fiasp
6. Contents of the pack and other information

1. What Fiasp is and what it is used for

Fiasp is an insulin administered at mealtime with a rapid blood glucose-lowering effect. Fiasp is an injectable solution of insulin aspart and is used to treat diabetes mellitus in adults, adolescents, and children from 1 year of age. Diabetes is a condition in which the body does not produce enough insulin to control blood sugar levels. Treatment with Fiasp helps prevent complications of diabetes. Fiasp should be injected from 2 minutes before starting to eat, with the possibility of administration up to 20 minutes after the start of the meal. This medicine reaches its maximum effect between 1 and 3 hours after injection, and the effect lasts between 3 and 5 hours.

This medicine should usually be used in combination with intermediate- or long-acting insulins.

2. What you need to know before using Fiasp

Do not use Fiasp

• if you are allergic to insulin aspart or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Talk to your doctor, pharmacist, or nurse before using Fiasp. It is important that you are aware of the following:

• Low blood sugar (hypoglycemia): if your blood sugar level is too low, follow the instructions for low blood sugar provided in section 4 “Possible side effects”. Compared to other insulins taken at mealtime, Fiasp begins lowering blood sugar faster. If you experience hypoglycemia, you may feel it sooner after an injection of Fiasp.
• High blood sugar (hyperglycemia): if your blood sugar level is too high, follow the instructions for high blood sugar provided in section 4 “Possible side effects”.
• Switching from other insulins: your doctor may need to advise you on your insulin dose.
• If you are combining your insulin treatment with pioglitazone (an oral antidiabetic medicine used to treat type 2 diabetes), speak to your doctor as soon as possible if you experience symptoms of heart failure such as unusual shortness of breath, rapid weight gain, or localized swelling due to fluid retention (edema).
• Eye disorders: a sudden improvement in blood sugar control may temporarily worsen diabetes-related eye problems such as diabetic retinopathy.
• Nerve pain: if your blood sugar level improves very rapidly, you may experience nerve-related pain, which is usually temporary.
• Swelling of joints: when you first start using the medicine, your body may retain more fluid than normal, causing swelling of the ankles and other joints. This effect usually disappears quickly.
• Make sure you are using the correct type of insulin; always check the insulin label before each injection to avoid accidental mix-ups between insulins.
• Treatment with insulin may cause your body to produce antibodies against insulin (substances that act against insulin). However, very rarely, this may require a change in your insulin dose.

In case of reduced vision, see section 3 “How to use Fiasp”.

Certain conditions and activities may affect your insulin requirements. Consult your doctor:

• if you have kidney, liver, adrenal, pituitary, or thyroid gland problems.
• if you are doing more physical exercise than usual or wish to change your normal diet, as this may affect your blood sugar level.
• if you are unwell, continue your insulin treatment and consult your doctor.
• if you are traveling abroad, traveling across different time zones may affect your insulin needs and injection times.

When using Fiasp, it is strongly recommended that you record the name and batch number of each container to maintain a record of the batches used.

Skin changes at the injection site

You should rotate your injection site to help prevent changes in fatty tissue, such as thickening of the skin, skin shrinkage, or lumps under the skin. Insulin may not work as well if injected into a lumpy, shrunken, or thickened area (see section 3 “How to use Fiasp”). Inform your doctor if you notice any changes at the injection site. Inform your doctor if you are currently injecting into these affected areas before switching to a different site. Your doctor may advise you to monitor your blood sugar levels more closely and may adjust your insulin or the dose of your other antidiabetic medications.

Children and adolescents

This medicine is not recommended for use in children under 1 year of age.

Other medicines and Fiasp

Tell your doctor or pharmacist if you are taking, have recently taken, or might need to take any other medicines. Some medicines affect your blood sugar level, which may require adjustment of your insulin dose.

The main medicines that may affect your insulin treatment are listed below.

Your blood sugar level may decrease (hypoglycemia) if you take:

• other diabetes medicines (oral or injectable)
• sulfonamide antibiotics (used to treat infections)
• anabolic steroids (such as testosterone)
• beta-blockers (used to treat high blood pressure or angina)
• salicylates (used to relieve pain and reduce fever)
• monoamine oxidase inhibitors (MAOIs) (used to treat depression)
• angiotensin-converting enzyme inhibitors (ACE inhibitors) (used to treat certain heart conditions or high blood pressure).

Your blood sugar level may increase (hyperglycemia) if you take:

• danazol (a medicine that affects ovulation)
• oral contraceptives (birth control pills)
• thyroid hormones (to treat thyroid gland problems)
• growth hormone (to treat growth hormone deficiency)
• glucocorticoids (such as “cortisone”, to treat inflammation)
• sympathomimetics (such as epinephrine (adrenaline), salbutamol, or terbutaline, used to treat asthma)
• thiazides (to treat high blood pressure or fluid retention).

Octreotide and lanreotide, used to treat acromegaly, a rare disorder characterized by excessive growth hormone production, may either increase or decrease your blood sugar level.

If you are in any of the above situations (or are unsure), consult your doctor or pharmacist.

Use of Fiasp with alcohol

Drinking alcohol may alter your insulin requirements, as it may increase or decrease your blood sugar level. Therefore, you should monitor your blood sugar level more frequently than usual.

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant, or plan to become pregnant, consult your doctor before using this medicine. This medicine can be used during pregnancy, but your insulin dose may need to be adjusted during pregnancy and after childbirth. Your insulin requirement usually decreases during the first 3 months of pregnancy and increases during the remaining 6 months. Careful diabetes control is necessary during pregnancy. Preventing low blood sugar (hypoglycemia) is especially important for your baby’s health. After delivery, your insulin requirements will likely return to what they were before pregnancy.

There are no restrictions on the use of Fiasp during breastfeeding.

Driving and using machines

Low blood sugar may affect your ability to drive or operate tools or machinery. If your blood sugar is low, your concentration and reaction time may be impaired. This could endanger your life or the lives of others. Ask your doctor if you are allowed to drive if:

• you experience frequent episodes of hypoglycemia
• you have difficulty recognizing the symptoms of hypoglycemia.

Important information about some of the ingredients of Fiasp

This medicine contains less than 1 mmol of sodium (23 mg) per dose; essentially “sodium-free”.

3. How to use Fiasp

Follow exactly the administration instructions for this medicine given by your doctor. If in doubt, consult your doctor or pharmacist again.

If you are blind or have reduced vision and cannot read the dose counter on the pen, do not use this pen without assistance. Ask for help from a person with normal vision who has been trained in the use of the FlexTouch pre-filled pen.

The pre-filled pen can deliver a dose of 1–80 units in one injection, in 1-unit increments.

When to use Fiasp

Fiasp is an insulin that is administered at mealtime.

Adults: Fiasp should be injected just before (0 to 2 minutes before) starting to eat, with the possibility of administering it up to 20 minutes after the start of the meal.

Children: Fiasp should be injected just before (0 to 2 minutes before) starting to eat, with the possibility of administering it up to 20 minutes after the start of the meal in situations where it is uncertain when the child will eat. Consult your doctor about these situations.

This medicine reaches its maximum effect between 1 and 3 hours after injection, and the effect lasts between 3 and 5 hours.

Dose of Fiasp

Dose for type 1 and type 2 diabetes

Your doctor will decide together with you:

• how much Fiasp you need at each meal
• when to check your blood sugar level and whether you need a higher or lower dose.

If you wish to modify your usual diet, consult your doctor, pharmacist, or nurse beforehand, as a change in diet may alter your insulin requirement.

When using other medicines, ask your doctor whether your treatment needs to be adjusted.

Dose adjustment for type 2 diabetes

The daily dose depends on your blood sugar level at mealtimes the previous day and the previous night.

• Before breakfast: the dose should be adjusted according to the blood sugar level before lunch the previous day.
• Before lunch: the dose should be adjusted according to the blood sugar level before dinner the previous day.
• Before dinner: the dose should be adjusted according to the blood sugar level the previous night.

Table 1 Dose adjustment
Blood sugar level at mealtime or at night	Dose adjustment
mmol/l	mg/dl
less than 4	less than 71	Reduce dose by 1 unit
4–6	71–108	No dose adjustment needed
more than 6	more than 108	Increase dose by 1 unit

Use in elderly patients (65 years of age or older)

This medicine can be used in elderly patients. Speak with your doctor about possible dose adjustments.

If you have kidney or liver problems

If you have kidney or liver problems, you may need to monitor your blood sugar level more frequently. Speak with your doctor about possible dose adjustments.

Injecting Fiasp

This medicine is intended only for injection under the skin (subcutaneous injection).

Before using Fiasp for the first time, your doctor or nurse will show you how to use the prefilled pen. Consult your doctor if you need to inject insulin by another method.

Where to inject

• The best areas for injection are the front of the waist (abdomen) or the upper arm.
• Do not inject into a vein or muscle.
• Change the injection site daily within the area where you inject to reduce the risk of developing skin changes (see section 4).

Do not use Fiasp

• if the pen is damaged or has not been stored properly (see section 5 “Storage of Fiasp”).
• if the insulin does not appear clear (e.g., cloudy) and colorless.

Detailed instructions on how to use the FlexTouch pen are provided on the reverse side of this leaflet.

If you use more Fiasp than you should

If you use too much insulin, your blood sugar level may become very low (hypoglycaemia); see section 4 “Low blood sugar level”.

If you forget to use Fiasp

If you forget to inject your insulin, your blood sugar level may become very high (hyperglycaemia). See section 4 “High blood sugar level”.

Three simple steps that may help you avoid low or high blood sugar levels:

• Always carry a spare pen in case you lose or damage yours.
• Always carry something that indicates you are diabetic.
• Always carry sugary products with you. See section 4 “What to do if your blood sugar level is low”.

If you stop using Fiasp

Do not stop treatment with your insulin without consulting your doctor. Stopping insulin administration may lead to very high blood sugar levels (severe hyperglycaemia) and ketoacidosis (a condition involving excessive acid in the blood, which can be life-threatening). See symptoms and recommendations in section 4 “High blood sugar level”.

4. Possible adverse effects

Like all medicines, this medicine can cause adverse effects, although not everyone will experience them.

Low blood sugar (hypoglycaemia) is a very common side effect of insulin treatment (it may affect more than 1 in 10 people). It can be very serious. Severe hypoglycaemia may lead to loss of consciousness. Severe hypoglycaemia can cause brain damage and may be life-threatening. If you experience symptoms of low blood sugar, take action to raise your blood sugar level immediately. See the recommendations below under “Low blood sugar”.

If you experience a severe allergic reaction (including anaphylactic shock) to insulin or to any of the components of Fiasp (the frequency of this is unknown), stop treatment with this medicine and contact emergency medical services immediately.

Symptoms of a severe allergic reaction may include:

• local reactions (e.g. rash, redness, itching) spreading to other parts of the body
• sudden feeling of being unwell with sweating
• starting to vomit
• experiencing difficulty breathing
• palpitations or feeling dizzy.

Allergic reactions such as generalized skin rash and facial swelling may occur. These are uncommon and may affect up to 1 in 100 people. Consult a doctor if symptoms worsen or if you do not see improvement within a few weeks.

Skin changes at the injection site: If you inject insulin in the same place repeatedly, fatty tissue may shrink (lipoatrophy) or become thicker (lipohypertrophy) (these are uncommon and may affect up to 1 in 100 people). Lumps under the skin may also occur due to accumulation of a protein called amyloid (cutaneous amyloidosis; frequency unknown). Insulin may not work as well if injected into a lumpy, shrunken, or thickened area. Rotate your injection sites to help prevent these skin changes.

Other adverse effects include:

Common (may affect up to 1 in 10 people)

Reaction at the injection site: Local reactions at the injection site may occur. Symptoms may include rash, redness, swelling, bruising, irritation, pain, and itching. These reactions usually disappear after a few days.

Skin reactions: Skin allergy signs such as eczema, rash, itching, hives, and dermatitis may occur.

General effects of insulin treatment including Fiasp

• Low blood sugar (hypoglycaemia) (very common)

Low blood sugar may occur if you:

Drink alcohol, inject too much insulin, exercise more than usual, eat too little, or skip a meal.

Warning signs of low blood sugar, which may appear suddenly: Headache, difficulty speaking, palpitations, cold sweat, cold and pale skin, nausea, excessive hunger, trembling, nervousness or anxiety, unusual tiredness, weakness, and drowsiness, confusion, difficulty concentrating, temporary changes in vision.

What to do if your blood sugar is low

• If you are conscious, treat your low blood sugar immediately with 15–20 g of fast-acting carbohydrates: take glucose tablets or a sugary product such as fruit juice, sweets, or biscuits (always carry glucose tablets or sugary products with you in case you need them).
• It is recommended to recheck your blood glucose levels after 15–20 minutes and treat again if your blood glucose levels are still below 4 mmol/l.
• Wait until symptoms of hypoglycaemia have disappeared or your blood sugar level has stabilized. Continue insulin treatment as usual.

What people close to you should do if you lose consciousness

Inform people you spend time with that you have diabetes. Tell them what the consequences of low blood sugar may be, including the risk of losing consciousness.

Inform them that if you become unconscious, they should:

• lay you on your side to prevent choking
• seek immediate medical assistance
• not give you anything to eat or drink, as you could choke.

You may regain consciousness more quickly if someone who knows how to do it administers a glucagon injection.

• If glucagon is administered, you should take glucose or a sugary product as soon as you regain consciousness.
• If you do not respond to glucagon treatment, you must be treated in a hospital.

If severe hypoglycaemia is not treated, it may eventually cause brain damage, which may be temporary or permanent, and may even lead to death.

Talk to your doctor if:

• your blood sugar has been so low that you lost consciousness
• you have received a glucagon injection
• you have had several episodes of low blood sugar recently.

You may need to adjust the dose or frequency of your insulin injections, your diet, or your exercise routine.

• High blood sugar (hyperglycaemia)

High blood sugar may occur if you:

Eat more or exercise less than usual, drink alcohol, have an infection or fever, do not inject enough insulin, repeatedly inject less insulin than you need, forget to inject insulin, or stop insulin treatment.

Warning signs of high blood sugar, which usually appear gradually: Flushed skin, dry skin, feeling drowsy or tired, dry mouth, fruity breath odour (acetone), increased need to urinate, thirst, loss of appetite, nausea, or vomiting.

These may be symptoms of a very serious condition called ketoacidosis. This is an accumulation of acid in the blood due to the body metabolizing fat instead of sugar. If untreated, it could lead to diabetic coma and even death.

What to do if your blood sugar is high

• Check your blood sugar level.
• Administer a correction dose of insulin if you have been instructed how to do so.
• Check the level of ketones in your urine.
• If you have ketones, seek immediate medical assistance.

Reporting of adverse effects

If you experience any adverse effects, talk to your doctor, pharmacist, or nurse, even if they are adverse effects not listed in this leaflet. You can also report them directly via the Spanish Pharmacovigilance System for Human Medicines: https://www.notificaram.es. By reporting adverse effects, you can help provide more information on the safety of this medicine.

5. Storage of Fiasp

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the label and packaging following EXP. The expiry date refers to the last day of the month indicated.

Before first use

Store in a refrigerator (between 2°C and 8°C). Do not freeze. Keep away from the freezer compartment. Keep the pen with the cap on to protect it from light.

After first use or when carried as a spare

You may carry your pre-filled pen (FlexTouch) with you and store it at room temperature (not above 30°C) or in the refrigerator (between 2°C and 8°C) for up to 4 weeks. Always keep the pen with the cap on when not in use to protect it from light.

Medicines must not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines and packaging you no longer need. This will help protect the environment.

6. Contents of the pack and other information

Composition of Fiasp

• The active substance is insulin aspart. 1 ml of solution contains 100 units of insulin aspart. Each pre-filled pen contains 300 units of insulin aspart in 3 ml of solution.
• The other components are phenol, metacresol, glycerol, zinc acetate, sodium dihydrogen phosphate dihydrate, arginine hydrochloride, nicotinamide (vitamin B3), hydrochloric acid (for pH adjustment), sodium hydroxide (for pH adjustment) (see end of section 2 “Important information about some of the components of Fiasp”) and water for injections.

Appearance of Fiasp and contents of the pack

Fiasp is a clear, colourless, aqueous, injectable solution in a pre-filled pen.

Pack sizes of 1, 5 or multiple packs with 2 × 5 pre-filled pens of 3 ml. Only certain pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Novo Nordisk A/S,
Novo Allé,
DK-2880 Bagsværd, Denmark

Date of the most recent revision of this leaflet:

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

Instructions for using Fiasp FlexTouch

Read these instructions carefully before using your pre-filled FlexTouch pen. If you do not follow these instructions carefully, you may inject too little or too much insulin, which could cause your blood sugar level to become too high or too low.

Do not use the pen without proper training from your doctor or nurse.

Begin by checking the pen to ensure it contains Fiasp 100 units/ml, then review the illustrations to become familiar with the different parts of the pen and the needle.

If you are blind or have reduced vision and cannot read the dose counter on the pen, do not use this pen without assistance. Seek help from a person with normal vision who has been trained in the use of the FlexTouch pre-filled pen.

Your pen is a pre-filled insulin dosing pen containing 300 units of insulin. It allows you to select a maximum dose of 80 units per injection in 1-unit increments. The pen is designed to be used with disposable single-use needles from 4 mm to 8 mm in length and with a gauge from 30 G to 32 G. Needles are not included in the pack.

Important information

Pay special attention to these notes, as they are important for the correct use of the pen.

1 Preparing the pen with a new needle

• Check the name and concentration on the label of your pen to ensure it contains Fiasp 100 units/ml. This is especially important if you use more than one type of insulin. Using the wrong type of insulin may cause your blood sugar level to become too high or too low.

• Remove the pen cap.

• Check that the insulin in the pen appears clear and colourless.

Look through the insulin window. Do not use the pen if the insulin appears cloudy.

• Take a new needle and remove the paper tab.

Ensure the needle is properly positioned.

• Place the needle straight onto the pen.
• Screw it on tightly.

Needles are covered by two caps. You must remove both caps. If you forget to remove both, no insulin will be injected.

• Remove the outer needle cap and keep it for later. You will need it after the injection to safely remove the needle from the pen.

• Remove the inner needle cap and discard it. If you try to reattach it, it may become damaged or you may accidentally prick yourself with the needle.

A drop of insulin may appear at the needle tip. This is normal, but you must still check the insulin flow.

Do not attach a new needle to the pen until you are ready to administer the injection.

Always use a new needle for each injection.

This reduces the risk of contamination, infection, insulin leakage, blocked needles, and inaccurate dosing.

Never use a bent or damaged needle.

2 Checking insulin flow

• Always check the insulin flow before starting.

This helps ensure you receive the full dose of insulin.

• Turn the dose selector to select 2 units. Make sure a "2" appears in the dose counter.

• Hold the pen with the needle pointing upwards.

Gently tap the top of the pen several times to bring any air bubbles to the surface.

• Press and hold the dose button until the dose counter returns to 0.

The "0" must align with the dose marker.

A drop of insulin should appear at the needle tip.

A small air bubble may remain at the needle tip, but it will not be injected.

If a drop does not appear, repeat steps 2A to 2C up to 6 times. If no drop appears after that, change the needle and repeat steps 2A to 2C once more.

If still no drop appears, discard the pen and use a new one.

Always ensure a drop appears at the needle tip before injecting. This ensures insulin flows properly.

If no drop appears, no insulin will be injected, even if the dose counter moves. This may indicate a blocked or damaged needle.

Always check insulin flow before injecting. If you do not check the flow, you may receive an insufficient or no insulin dose, which could cause your blood sugar level to rise.

3 Selecting the dose

• Check that the dose counter shows 0 before starting.

The "0" must align with the dose marker.

• Turn the dose selector to select the dose you need, following your doctor’s or nurse’s instructions.

If you select the wrong dose, you can turn the dose selector forward or backward to correct it.

The pen allows a maximum dose of 80 units.

The dose selector changes the number of units. Only the dose counter and dose marker show how many units you have selected for each administration.

You can select up to 80 units per injection. When less than 80 units remain in the pen, the dose counter stops when it reaches the number of units left.

Before injecting insulin, always use the dose counter and dose marker to verify how many units you have selected.

Do not count the clicks of the pen to set the dose. If you select and inject the wrong dose, your blood sugar level may become too high or too low.

Do not use the insulin scale, as it only shows the approximate amount of insulin remaining in the pen.

The dose selector clicks differently when turned forward, backward, or past the number of units remaining.

4 Injecting the dose

• Insert the needle under the skin, as instructed by your doctor or nurse.

•Ensure you can see the dose counter.

Do not touch the dose counter with your fingers. This may interrupt the injection.

• Press and hold the dose button. Watch the dose counter return to 0.

The "0" must align with the dose marker. You may hear or feel a click at this point.

•Continue holding the dose button while keeping the needle in the skin.

• Count slowly to 6 while holding the dose button down.
• If you remove the needle too early, you may see insulin leaking from the needle tip. This means the full dose was not administered, so you should monitor your blood sugar level more frequently.

• Remove the needle from the skin. Then release the dose button.

If you see blood at the injection site, apply light pressure to the skin for a few minutes to stop bleeding. Do not rub the area.

A drop of insulin may appear at the needle tip after injection. This is normal and does not affect the dose.

Always watch the dose counter to confirm how many units you are injecting. Keep the dose button pressed until the dose counter shows 0. If the counter does not return to 0, the full dose was not administered, which could cause your blood sugar level to rise.

How to detect if the needle is blocked or damaged?

• If the dose counter does not return to 0 after continuously pressing the dose button, you may have used a blocked or damaged needle.
• In this case, you will not have received any medication, even if the dose counter moved from the original dose set.

What to do if the needle is blocked?

Remove the needle as described in section 5 and repeat all steps from section 1: Preparing the pen with a new needle. Be sure to select the full dose you need.

Never touch the dose counter during injection.

This may interrupt the injection.

5 After injection

Always dispose of the needle after each injection.

This reduces the risk of contamination, infection, insulin leakage, blocked needles, and inaccurate dosing. If the needle is blocked, no insulin will be injected.

• Insert the needle tip into the outer cap placed on a flat surface, without touching the needle or outer cap.

• Once the needle is covered, press the outer cap down firmly and carefully.

• Unscrew the needle and dispose of it carefully as instructed by your doctor, nurse, pharmacist, or local authorities.

• Replace the pen cap after each use to protect the insulin from light.

When the pen is empty, discard it without the needle attached, following instructions from your doctor, nurse, pharmacist, or local authorities.

Never attempt to reattach the inner needle cap. You may prick or injure yourself.

Always remove the needle from the pen after each injection and store your pen without a needle attached. This reduces the risk of contamination, infection, insulin leakage, blocked needles, and inaccurate dosing.

6 How much insulin remains?

• The insulin scale shows the approximate amount of insulin remaining in the pen.

• To determine the exact amount of insulin remaining, use the dose counter:

Turn the dose selector until the dose counter stops.

If it shows 80, at least 80 units remain in the pen.

If it shows less than 80, the number indicates the exact number of units remaining.

• Turn the dose selector back until the dose counter shows 0.

• If you need more insulin than remains in the pen, you may split the dose between two pens.

Be very careful when calculating if splitting your dose.

If you are unsure, inject the full dose using a new pen. Incorrectly splitting the dose may result in too little or too much insulin being injected, which could cause your blood sugar level to become too high or too low.

Additional important information

• Always carry the pen with you.

• Always carry a spare pen and new needles in case of loss or breakage.

• Always keep the pen and needles out of sight and reach of others, especially children.

• Never share the pen or needles with other people. Infections may occur.

• Never share the pen with other people. Your medication may be harmful to others.

• People caring for patients must be very careful when handling used needles to reduce the risk of needle-stick injury and infection.

Pen care

• Handle your pen with care. Rough handling or misuse may cause inaccurate dosing, which could cause your blood sugar level to become too high or too low.

• Do not leave the pen in a car or in places where it may become too hot or too cold.

• Do not expose the pen to dust, dirt, or liquids.

• Do not wash, soak, or lubricate the pen. If necessary, clean it with a damp cloth using a mild detergent.

• Avoid dropping the pen or knocking it against hard surfaces.

If the pen is dropped or you suspect it may be damaged, attach a new needle and check insulin flow before injecting.

• Do not attempt to refill the pen. Once empty, it must be discarded.

Do not attempt to repair or disassemble the pen.