Ciprofloxacin Kern Pharma 2 mg/ml solution for infusion EFG: detailed information

Package leaflet: Information for the user

Introduction

Package leaflet: information for the user

Ciprofloxacin Kern Pharma 2 mg/ml solution for infusion EFG

Read all of this leaflet carefully before you start using this medicine, because it contains important information for you.

Keep this leaflet, as you may need to read it again.
If you have any questions, ask your doctor, pharmacist or nurse.
This medicine has been prescribed for you only and must not be given to other people, even if they have the same symptoms as you, because it may harm them.
If you experience any side effects, talk to your doctor or pharmacist, even if they are side effects not listed in this leaflet. See section 4.

Leaflet contents:

What Ciprofloxacin Kern Pharma is and what it is used for
What you need to know before using Ciprofloxacin Kern Pharma
How to use Ciprofloxacin Kern Pharma
Possible side effects
How to store Ciprofloxacin Kern Pharma
Contents of the pack and other information

1. What Ciprofloxacin Kern Pharma is and what it is used for

Ciprofloxacin Kern Pharma contains the active substance ciprofloxacin. Ciprofloxacin is an antibiotic belonging to the fluoroquinolone group. Ciprofloxacin works by eliminating bacteria that cause infections. It only acts against specific strains of bacteria.

Antibiotics are used to treat bacterial infections and are not effective against viral infections such as influenza or the common cold.

It is important that you follow your doctor's instructions regarding dosage, dosing interval, and duration of treatment.

Do not store or reuse this medicine. If you have any antibiotic left after completing treatment, return it to the pharmacy for proper disposal. Medicines must not be disposed of via wastewater or household waste.

Adults

Ciprofloxacin is used in adults to treat the following bacterial infections:

Certain respiratory tract infections.
Certain long-lasting or recurrent ear or sinus infections.
Urinary tract infections.
Genital tract infections in both women and men.
Gastrointestinal and intra-abdominal infections.
Skin and soft tissue infections.
Bone and joint infections.
Treatment following inhalation of anthrax-causing pathogens.

Ciprofloxacin may also be used to treat patients with low counts of certain white blood cells (neutropenia) who have a fever suspected to be due to a bacterial infection.

If you have a severe infection or if the infection is caused by more than one type of bacteria, you may be given an additional antibiotic treatment along with ciprofloxacin.

Children and adolescents

Ciprofloxacin is used in children and adolescents, under specialized medical supervision, to treat the following bacterial infections:

Lung and bronchial infections in children and adolescents with cystic fibrosis,
Complicated urinary tract infections, including infections affecting the kidneys (pyelonephritis),
Treatment following inhalation of anthrax-causing pathogens.

Ciprofloxacin may also be used to treat severe infections in children and adolescents when deemed necessary.

2. What you need to know before using Ciprofloxacin Kern Pharma

Do not use Ciprofloxacin Kern Pharma

If you are allergic to ciprofloxacin, to other quinolones, or to any of the other components of this medicine (listed in section 6).
If you are taking tizanidine (see section 2: Other medicines and Ciprofloxacin Kern Pharma).

Warnings and precautions

Before you are given this medicine

Do not take antibacterial medicines containing fluoroquinolones or quinolones, including ciprofloxacin, if you have previously experienced a serious adverse reaction to a quinolone or fluoroquinolone. If this applies to you, inform your doctor as soon as possible.

Talk to your doctor, pharmacist, or nurse before you are given ciprofloxacin:

if you have ever had kidney problems, as your treatment may need dose adjustment
if you have epilepsy or other neurological conditions
if you have a history of tendon problems during previous treatment with antibiotics such as ciprofloxacin
if you have diabetes, as you may be at risk of hypoglycemia with ciprofloxacin
if you have myasthenia gravis (a type of muscle weakness), as symptoms may worsen
if you have been diagnosed with an enlarged blood vessel or a "bulge" in a large blood vessel (aortic aneurysm or peripheral large-vessel aneurysm)
if you have previously experienced aortic dissection (a tear in the wall of the aorta)
if you have been diagnosed with heart valve insufficiency (regurgitation of heart valves)
if you have a family history of aortic dissection or aortic aneurysm, congenital heart valve disease, or other risk factors or predisposing conditions (e.g., connective tissue disorders such as Marfan syndrome, vascular Ehlers-Danlos syndrome, Turner syndrome, or Sjögren's syndrome (an inflammatory autoimmune disease), or vascular disorders such as Takayasu arteritis, giant cell arteritis, Behçet’s disease, hypertension, known atherosclerosis, rheumatoid arthritis (a joint disease), or endocarditis (a heart infection))
if you have heart problems. Caution is advised when using this type of medicine if you were born with or have a family history of QT interval prolongation (seen on ECG, a recording of the heart's electrical activity), have an electrolyte imbalance (especially low blood potassium or magnesium levels), have a very slow heart rate (called "bradycardia"), have weak heart function (heart failure), have a history of heart attacks (myocardial infarction), are female, are elderly, or are taking other medicines that may cause ECG changes (see section 2: “Use of other medicines and Ciprofloxacin”)
if you or a family member has a confirmed deficiency of glucose-6-phosphate dehydrogenase (G6PD), as you may be at risk of anemia with ciprofloxacin.

For the treatment of certain genital tract infections, your doctor may prescribe another antibiotic in addition to ciprofloxacin. If there is no improvement in symptoms after 3 days of treatment, consult your doctor.

During treatment with this medicine

Inform your doctor immediately if any of the following occur during treatment with ciprofloxacin. Your doctor will decide whether treatment with ciprofloxacin should be discontinued.

Severe and sudden allergic reaction (anaphylactic reaction or angioedema). There is a small chance that even with the first dose, you may experience a severe allergic reaction with symptoms such as chest tightness, dizziness, nausea, faintness, or dizziness upon standing. If this occurs, inform your doctor immediately, as ciprofloxacin administration must be stopped.
Severe, disabling, long-lasting, and potentially irreversible adverse effects Antibacterial medicines containing fluoroquinolones or quinolones, including ciprofloxacin, have been associated with rare but serious adverse effects, some of which were long-lasting (persisting for months or years), disabling, or potentially irreversible. These include tendon, muscle, and joint pain in the upper and lower limbs, difficulty walking, abnormal sensations such as pricking, tingling, pins and needles, numbness, or burning (paresthesia), sensory disturbances such as reduced vision, taste, smell, or hearing, depression, memory impairment, extreme fatigue, and severe sleep disturbances (see section 4). If you experience any of these adverse effects after taking ciprofloxacin, contact your doctor immediately before continuing treatment. You and your doctor will decide whether to continue treatment, possibly considering the use of an antibiotic from another class.
Rarely, joint pain and swelling, or tendon inflammation or rupture may occur. The risk is higher if you are elderly (over 60 years), have received an organ transplant, have kidney problems, or are taking corticosteroids. Tendon inflammation and rupture may occur within the first 48 hours of treatment or even several months after stopping ciprofloxacin. At the first sign of tendon pain or swelling (e.g., in the ankle, wrist, elbow, shoulder, or knee), stop taking ciprofloxacin, contact your doctor, and rest the affected area. Avoid unnecessary physical activity, as this may increase the risk of tendon rupture.
If you experience sudden and severe pain in the abdomen, chest, or back, which may be symptoms of aortic dissection or aneurysm, go immediately to an emergency department. The risk may increase if you are receiving systemic corticosteroid treatment.
If you suddenly develop shortness of breath, especially when lying down, or notice swelling in your ankles, feet, or abdomen, or the onset of palpitations (a sensation of rapid or irregular heartbeat), inform your doctor immediately.
If you have epilepsy or another neurological condition, such as cerebral ischemia or stroke, you may experience central nervous system-related adverse effects. If this occurs, stop using ciprofloxacin and contact your doctor immediately.
Rarely, you may experience symptoms of nerve damage (neuropathy) such as pain, burning, tingling, numbness, and/or weakness, especially in the feet and legs or hands and arms. If this occurs, stop taking ciprofloxacin and inform your doctor immediately to prevent potentially permanent damage.
You may experience psychiatric reactions after the first dose of ciprofloxacin. If you have depression or psychosis, your symptoms may worsen with ciprofloxacin treatment. In rare cases, depression or psychosis may progress to suicidal thoughts, suicide attempts, or completed suicide. If this occurs, stop using ciprofloxacin and contact your doctor immediately.
Quinolone antibiotics may cause an increase in blood sugar levels above normal (hyperglycemia), or a decrease in blood sugar levels below normal, which in severe cases may lead to loss of consciousness (hypoglycemic coma) (see section 4). This is particularly important for people with diabetes. If you have diabetes, your blood sugar levels should be closely monitored.
Diarrhea may develop during antibiotic use, including ciprofloxacin, or even several weeks after stopping treatment. If it becomes severe or persistent, or if you notice blood or mucus in your stools, inform your doctor immediately. Treatment with ciprofloxacin must be stopped immediately, as this may be life-threatening. Do not take medications that stop or delay intestinal movements.
If your vision worsens or your eyes are otherwise affected, consult an ophthalmologist immediately.
Your skin may become more sensitive to sunlight or ultraviolet (UV) light during treatment with ciprofloxacin. Avoid exposure to intense sunlight or artificial UV light, such as tanning beds.
While using ciprofloxacin, inform your doctor or laboratory staff if you need to undergo a blood or urine test.
If you have kidney problems, inform your doctor, as your dose may need to be adjusted.
Ciprofloxacin may cause liver damage. If you notice symptoms such as loss of appetite, jaundice (yellowing of the skin), dark urine, itching, or stomach pain, stop taking ciprofloxacin immediately.
Ciprofloxacin may cause a decrease in white blood cell count and possibly reduce your resistance to infections. If you develop an infection with symptoms such as fever and severe deterioration in your general condition, or fever with signs of local infection such as sore throat/pharynx/mouth, or urinary problems, consult your doctor immediately. A blood test will be performed to check for possible low white blood cell count (agranulocytosis). It is important to inform your doctor about your medication.

Use of other medicines

Inform your doctor or pharmacist if you are taking, have recently taken, or might need to take any other medicines.

Do not use ciprofloxacin at the same time as tizanidine, as this may cause adverse effects such as low blood pressure and drowsiness (see section 2: “Do not use Ciprofloxacin Kern Pharma”).

The following medicines are known to interact with ciprofloxacin in your body. If you take ciprofloxacin at the same time as these medicines, this may affect the therapeutic effect of these medicines or increase the risk of adverse effects.

Inform your doctor if you are taking:

Vitamin K antagonists (e.g., warfarin, acenocoumarol, fenprocoumon, fluindione) or other oral anticoagulants (to thin the blood)
probenecid (for gout)
methotrexate (for certain types of cancer, psoriasis, rheumatoid arthritis)
theophylline (for respiratory problems)
tizanidine (for muscle spasticity in multiple sclerosis)
olanzapine (an antipsychotic)
clozapine (an antipsychotic)
ropinirole (for Parkinson’s disease)
phenytoin (for epilepsy)
cyclosporine (for skin diseases, rheumatoid arthritis, and organ transplantation)
other medicines that may alter heart rhythm: medicines belonging to the antiarrhythmic group (e.g., quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, certain antimicrobials (macrolide group), and certain antipsychotics
zolpidem (for sleep disorders)

Ciprofloxacin may increase blood levels of the following medicines:

pentoxifylline (for circulatory disorders)
caffeine
duloxetine (for depression, diabetic nerve damage, or incontinence)
lidocaine (for heart conditions or anesthesia)
sildenafil (e.g., for erectile dysfunction)
agomelatine (for depression)

Use of Ciprofloxacin Kern Pharma with food and drinks

Food and drinks do not affect your treatment with ciprofloxacin.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before receiving this medicine.

It is preferable to avoid using ciprofloxacin during pregnancy.

Do not use ciprofloxacin while breastfeeding, as ciprofloxacin is excreted in breast milk and may harm your baby.

Driving and using machines

Ciprofloxacin may reduce your level of alertness. Some neurological effects may occur.

Therefore, make sure you know how you react to ciprofloxacin before driving a vehicle or operating machinery. If in doubt, consult your doctor.

Ciprofloxacin Kern Pharma contains sodium

This medicine contains 353.9 mg (15.4 mmol) of sodium (the main component of table/cooking salt) per 100 ml of infusion solution. This corresponds to 35.39% of the maximum daily recommended sodium intake for an adult.

3. How to use Ciprofloxacin Kern Pharma

Your doctor will explain exactly how much ciprofloxacin you should be given, how often, and for how long. This will depend on the type of infection you have and its severity.

Inform your doctor if you have kidney problems, as your dose may need to be adjusted.

Treatment usually lasts between 5 and 21 days, but may last longer for severe infections.

Your doctor will administer each dose as a slow intravenous infusion into your bloodstream. In children, the infusion duration is 60 minutes. In adult patients, the infusion time is 60 minutes for 400 mg of ciprofloxacin and 30 minutes for 200 mg of ciprofloxacin. Slow administration of the infusion helps prevent immediate adverse reactions.

Remember to drink plenty of fluids while receiving this medicine.

If your administration of Ciprofloxacin Kern Pharma is interrupted

It is important that you complete the full course of treatment, even if you start to feel better after a few days. If you stop using this medicine too soon, your infection may not be completely cured and symptoms may return or worsen. You may also develop antibiotic resistance.

If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

4. Possible adverse effects

Like all medicines, this medicine can cause adverse effects, although not everyone will experience them.

The following section describes the most serious adverse effects you can recognize yourself:

Stop taking ciprofloxacin and contact your doctor immediately to consider alternative antibiotic treatment if you notice any of the following serious adverse effects:

Uncommon (may affect up to 1 in 100 people)

seizures (see section 2: Warnings and precautions)

Rare (may affect up to 1 in 1,000 people)

severe and sudden allergic reaction with symptoms such as chest tightness, dizziness, nausea or fainting, or experiencing dizziness upon standing (anaphylactic shock) (see section 2: Warnings and precautions)
tendon rupture, particularly affecting the long tendon at the back of the ankle (Achilles tendon) (see section 2: Warnings and precautions)

Very rare (may affect up to 1 in 10,000 people)

severe and sudden allergic reaction with symptoms such as chest tightness, dizziness, nausea or fainting, or experiencing dizziness upon standing (anaphylactic reaction) (see section 2: Warnings and precautions)
muscle weakness, tendon inflammation that may lead to tendon rupture, especially of the long tendon at the back of the ankle (Achilles tendon) (see section 2: Warnings and precautions)
skin rashes with risk of death, typically presenting as blisters or ulcers in the mouth, throat, nose, eyes, and other mucous membranes such as the genitals, which may progress to widespread blistering or skin peeling (Stevens-Johnson syndrome, toxic epidermal necrolysis)

Frequency not known (cannot be estimated from available data)

unusual sensations of pain, burning, tingling, numbness, or muscle weakness in the limbs (neuropathy) (see section 2: Warnings and precautions)
a drug reaction causing skin rash, fever, internal organ inflammation, blood abnormalities, and systemic illness (DRESS - Drug Reaction with Eosinophilia and Systemic Symptoms, PEGA - Generalized Exanthematous Pustulosis)

Other adverse effects observed during ciprofloxacin treatment are listed below by their frequency:

Common (may affect up to 1 in 10 people):

nausea, diarrhea, vomiting
joint pain in children
local reaction at the injection site, skin rash
temporary increase in blood levels of certain substances (transaminases)

Uncommon (may affect up to 1 in 100 people):

joint pain in adults
fungal superinfections (infections caused by fungi)
elevated eosinophil count, a type of white blood cell; increase or decrease in a blood clotting factor (platelets)
decreased appetite
hyperactivity, agitation, confusion, disorientation, hallucinations
headache, dizziness, sleep disturbances or taste disorders, tingling and numbness, unusual sensitivity to sensory stimuli, seizures (see section 2: Warnings and precautions), vertigo
vision problems, including double vision
hearing loss
increased heart rate (tachycardia)
dilation of blood vessels (vasodilation), decreased blood pressure
abdominal pain, digestive problems such as slow digestion (indigestion/heartburn), flatulence
impaired liver function, increased blood levels of a substance (bilirubin), jaundice (cholestatic jaundice)
itching, hives
joint pain in adults
impaired kidney function, kidney failure
muscle and bone pain, feeling of malaise (asthenia), fever, fluid retention
increased alkaline phosphatase in blood (a blood substance)

Rare (may affect up to 1 in 1,000 people):

muscle pain, joint inflammation, increased muscle tone, cramps
inflammation of the intestine (colitis) associated with antibiotic use (may be fatal in very rare cases) (see section 2: Warnings and precautions)
changes in blood cell counts (leukopenia, leukocytosis, neutropenia, anemia), decreased number of red and white blood cells and platelets (pancytopenia) which may be life-threatening, bone marrow suppression which may be life-threatening (see section 2: Warnings and precautions)
allergic reaction, swelling (edema), or rapid swelling of the skin and mucous membranes (angioedema) (see section 2: Warnings and precautions)
increased blood sugar (hyperglycemia)
decreased blood sugar levels (hypoglycemia) (see section 2: Warnings and precautions)
anxiety reactions, strange dreams, depression (which may lead to suicidal thoughts, suicide attempts, and completed suicide), mental disturbances (psychotic reactions that may lead to suicidal thoughts, suicide attempts, and completed suicide) (see section 2: Warnings and precautions)
decreased skin sensitivity, tremors, migraine, disturbances in the sense of smell
ringing in the ears (tinnitus), hearing impairment
fainting, inflammation of blood vessels (vasculitis)
difficulty breathing, including asthma-like symptoms
inflammation of the pancreas (pancreatitis)
hepatitis, death of liver cells (hepatic necrosis), which very rarely leads to life-threatening liver failure (see section 2: Special warnings and precautions)
sensitivity to light (see section 2: Warnings and precautions), non-specific blister formation, small hemorrhages at points under the skin (petechiae)
blood or crystals in urine, inflammation of the urinary tract
excessive sweating
increased concentrations of the enzyme amylase

Very rare (may affect up to 1 in 10,000 people):

a specific type of decreased blood cell count (hemolytic anemia), a dangerous decrease in a type of white blood cells (agranulocytosis) (see section 2: Special warnings and precautions)
severe allergic reactions with risk of death (serum sickness) (see section 2: Special warnings and precautions)
coordination disorder, walking instability (gait disorders), increased pressure in the brain (intracranial pressure and pseudotumor cerebri)
visual distortions of colors
various skin rashes or exanthems
worsening of symptoms of myasthenia gravis (see section 2: Warnings and precautions)

Not known (frequency cannot be estimated from available data)

effect on blood clotting (in patients treated with vitamin K antagonists)
syndrome associated with deficient water secretion and low sodium concentrations (SIADH)
feeling highly excited (mania) or sensation of extreme optimism and hyperactivity (hypomania)
abnormally fast heart rate, irregular and potentially life-threatening heart rhythm, heart rhythm disturbances (known as "QT interval prolongation," observed on ECG, which is a recording of the heart's electrical activity)
loss of consciousness due to a severe drop in blood sugar levels (hypoglycemic coma). See section 2: Warnings and precautions

The use of antibiotics containing quinolones and fluoroquinolones has been associated with very rare cases of long-lasting (even months or years) or permanent adverse reactions, such as tendon inflammation, tendon rupture, joint pain, limb pain, difficulty walking, abnormal sensations such as pricking, tingling, pins and needles, burning, numbness or pain (neuropathy), depression, fatigue, sleep disturbances, memory impairment, and decreased hearing, vision, taste, and smell, even in some cases without pre-existing risk factors.

Cases of enlargement and weakening or tearing of the aortic wall (aneurysms and dissections), which could lead to rupture and may be fatal, and heart valve insufficiency have been reported in patients receiving fluoroquinolones. See also section 2.

Reporting of adverse effects

If you experience any adverse effect, consult your doctor, pharmacist, or nurse, even if it is a possible adverse effect not listed in this leaflet. You may also report them directly via the Spanish Pharmacovigilance System for Human Medicines: https://www.notificaram.es. By reporting adverse effects, you can help provide more information on the safety of this medicine.

5. Storage of Ciprofloxacin Kern Pharma

Keep out of the sight and reach of children.

Do not use Ciprofloxacin Kern Pharma after the expiry date stated on the package, after EXP. The expiry date refers to the last day of the month indicated.

Store below 25°C. Do not refrigerate or freeze, as crystals may form if the medicine is cooled too much. If you notice crystals in your medicine, do not use it and inform your doctor, nurse, or pharmacist immediately.

Always keep your medicine in its outer packaging to protect it from light.

Bottles with outer overwrap: Keep the bottles in the outer bag to protect them from light. Use immediately after removing the bag (see section 6.3).

Bottles without outer overwrap must be kept in the cardboard box to protect them from light. Use immediately after removing the cardboard box (see section 6.3).

Open the bottle and/or bag and use the medicine immediately. This is a single-dose container. No special storage precautions are required during the normal 60-minute infusion period.

Your medicine must not be mixed with other medicines that may also be administered by infusion. Ask your doctor, nurse, or pharmacist if you need further information on this.

Medicines must not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines and containers you no longer need. This will help protect the environment.

6. Contents of the pack and other information

Composition of Ciprofloxacin Kern Pharma

The active substance is ciprofloxacin (as lactate).

Each 100 ml contains 200 mg (milligrams) of ciprofloxacin. Each 200 ml contains 400 mg (milligrams) of ciprofloxacin.

The other components are lactic acid, sodium chloride, hydrochloric acid (for pH adjustment), and water for injections.

Appearance of Ciprofloxacin Kern Pharma and contents of the pack

Solution for infusion.

This means it is ready to be administered in a plastic bag or bottle as an intravenous infusion (drip).

Each bag or bottle of Ciprofloxacin contains 100 ml or 200 ml of your medicine.

Bags:

The 100 ml bags come in cardboard boxes of 10.
The 200 ml bags come in cardboard boxes of 5.

Bottles:

Each 100 ml bottle is placed inside a metallized plastic bag. Available in packs of 10 or 20 bottles.

Alternatively:

The 100 ml bottles are placed in cardboard boxes. Available in packs of 10 or 20 bottles.

Each 200 ml bottle is placed inside a metallized plastic bag. Available in packs of 10 and 20 bottles.

Alternatively:

The 200 ml bottles are placed in cardboard boxes. Available in packs of 10 or 20 bottles.

Only certain pack sizes may be marketed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Kern Pharma, S.L.

Venus 72, 72 – Pol. Ind. Colón II

08228 Terrassa – Barcelona

Spain

Manufacturer

DEMO S.A., 21st km National Road Athens-Lamia, 14568 Krioneri, Athens, Greece.

This medicinal product is authorized in the Member States of the European Economic Area under the following names:

Ireland: Ciprofloxacin 2 mg/ml Solution for Infusion

Spain: Ciprofloxacin Kern Pharma 2 mg/ml solution for infusion EFG

Austria: Ciprofloxacin Noridem 2 mg/ml Infusionslösung

Greece: Ciprofloxacin/Noridem, Διάλυμα για έγχυση 2 mg/ml

Germany: Ciprofloxacin 2mg/ml Infusionslösung

Date of the most recent review of this leaflet: February 2025

Detailed and up-to-date information on this medicinal product is available on the website of the Spanish Agency of Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Advice / Medical education

Antibiotics are used to treat bacterial infections. They are not effective against viral infections.

If your doctor has prescribed antibiotics, you need them specifically for your current illness.

Despite antibiotic treatment, some bacteria may survive or continue to grow. This phenomenon is known as resistance: some antibiotic treatments become ineffective.

Improper use of antibiotics increases the development of resistance. Even you can help bacteria become more resistant, thereby delaying your recovery or reducing the effectiveness of antibiotics if you do not follow:

the dose
the frequency of administration
the duration of treatment

Therefore, in order to maintain the effectiveness of this medicine:

Use antibiotics only when prescribed by a doctor.
Follow the dosage instructions throughout the entire duration of treatment.
Do not reuse an antibiotic without a medical prescription, even if you wish to treat a similar illness.
Never give your antibiotic to another person; it may not be suitable for their condition.
After completing a course of treatment, return all unused medicines to the pharmacy to ensure they are properly disposed of.

The following information is intended for healthcare professionals only

Ciprofloxacin Kern Pharma must be administered by intravenous infusion. In children, the infusion duration is 60 minutes. In adult patients, the infusion time is 60 minutes for 400 mg of Ciprofloxacin Kern Pharma, and 30 minutes for 200 mg of Ciprofloxacin Kern Pharma. A slow infusion into a large vein will minimize patient discomfort and reduce the risk of venous irritation. The solution for infusion may be administered directly or after mixing with another compatible infusion solution.

Unless compatibility with other infusion solutions or drugs has been confirmed, the infusion solution must always be administered separately. Visual signs of incompatibility include, for example, precipitation, turbidity, and color change.

Incompatibility occurs with all infusion solutions or drugs that are physically or chemically unstable at the pH of the solution (e.g., penicillins, heparin solutions), particularly when associated with solutions adjusted to an alkaline pH (pH of ciprofloxacin infusion solutions: 3.9 to 4.5).

After initiation of intravenous therapy, treatment may also be continued orally.