Oxygen medicinal gaseous

INSTRUCTION for medical use of medicinal product. Medical oxygen gas

Composition:

active substance: oxygen with a volume fraction of not less than 99.5%.

Pharmaceutical form. Gas.

Main physicochemical properties: colorless odorless and tasteless gas,
slightly soluble in water (approximately 1:43).

Pharmacotherapeutic group. Medical gases. ATC code V03AN01.

Pharmacological properties.

Pharmacodynamics.

Oxygen belongs to the group of anti-hypoxants and antioxidants. It has the ability to bind with blood hemoglobin in the lungs and, in a complex compound with heme, is transported to the body's cells. It is a strong oxidizing agent and an essential element in metabolic transformations of carbohydrates, proteins, and fats into energy substances necessary to sustain the body's vital functions.

Pharmacokinetics.

In the human body, oxygen diffuses through the lung tissue into the blood, binding to hemoglobin in erythrocytes and partially dissolving in plasma. Subsequently, oxygen is transported to body tissues, where it diffuses into the tissue interstitial fluid. The final stage of respiration is the utilization of oxygen in biological oxidation and the generation of energy within cells, followed by a series of transformations and eventual elimination via the lungs in the form of carbon dioxide (CO₂).

Clinical characteristics.

Indications.

Conditions associated with hypoxia:

respiratory organs:

• pneumonia;
• pulmonary edema;
• bronchial asthma;
• pneumosclerosis.

Cardiovascular system:

• heart failure;
• coronary insufficiency.

Poisonings:

• carbon monoxide;
• cyanide;
• choking gases.

During general anesthesia in combination with inhalation anesthetics; in the postoperative period.

Preparation of oxygen cocktails, foams.

Infectious diseases: ascariasis and trichuriasis.

Contraindications.

For hyperbaric oxygenation, contraindications include acute respiratory diseases, history of epileptic seizures, impaired patency of auditory tubes and canals connecting the paranasal sinuses, presence of lung cavities, bronchopleural fistulas, severe forms of arterial hypertension, neoplasms, increased individual sensitivity to oxygen.

For oxygen deworming, contraindications include gastric and duodenal peptic ulcers, tumors, and acute inflammatory diseases of the gastrointestinal tract.

Interaction with other medicinal products and other types of interactions.

Nitrates, beta-blockers, calcium ion antagonists, and nootropic agents promote more efficient tissue utilization of oxygen, thereby improving its utilization, reducing hypoxia, and increasing the body's resistance to oxygen deficiency.

Special precautions for use.

Do not use in women during menstruation.

The use with moisturizers is recommended.

Use during pregnancy or breastfeeding.

Do not use during pregnancy for longer than 5 months. Breastfeeding should be discontinued for the duration of drug use.

Ability to affect reaction speed when driving or operating machinery.

Due to possible dizziness, it is recommended to avoid driving a vehicle or performing tasks requiring increased attention and rapid reaction.

Administration and Dosage

In hospital settings, oxygen is most commonly administered via inhalation through special rubber or plastic masks connected directly to steel oxygen cylinders.

In outpatient practice and at home, special rubber or plastic containers (bags) filled with oxygen or its mixture are more frequently used.

For hyperbaric oxygenation, i.e., oxygen delivery under increased pressure, special ventilated chambers—so-called hyperbaric chambers (barochambers)—are used, where oxygen is administered both by inhalation and through mucous membranes and skin.

Most commonly, oxygen is administered by inhalation as a mixture with air at a concentration of 40–60%, at a flow rate of 4–5 liters per minute. A mixture called "carbogen," consisting of 95% oxygen and 5% carbon dioxide, is also used. The mixture should usually be administered humidified.

During hyperbaric oxygenation, oxygen is delivered under pressure of 1.2–2 atm. Therapeutically, 8–10 sessions are typically conducted.

For the treatment of ascariasis, oxygen is administered into the stomach via a thin gastric or duodenal tube. The tube should preferably be inserted through the nose. Oxygen is administered for 2 consecutive days, in the morning on an empty stomach or 4 hours after a meal. For children up to 10 years of age, administer 100 mL of oxygen per year of life; for children aged 10–12 years, 1000–1100 mL; for those aged 13–14 years, 1250 mL; and for patients aged 15 years and older, 1250–1500 mL. The oxygen should be administered slowly, in portions of 100–200–250 mL, with intervals of 1–2 minutes. The total volume should be administered over no less than 15 minutes. After the procedure, the patient must remain in a lying position for at least 2 hours.

For the treatment of trichocephalosis (infection with Trichocephalus trichiurus), the patient should first receive a cleansing enema. One hour later, with the patient lying on their side, a catheter (or a rubber enema tip) is inserted into the rectum to a depth of 25–30 cm (past the internal sphincter). Oxygen is then slowly insufflated in small portions (200–250 mL) at 2–3 minute intervals. For children under 10 years of age, administer 100 mL of oxygen per year of life; for children aged 10–12 years, 1000–1100 mL; for those aged 13–14 years, 1250 mL; and for patients aged 15 years and older, 1250–1500 mL. After completion of the procedure, the patient should lie on their back for 2 hours. Oxygen treatment should be continued for 5–7 consecutive days; on the 6th or 7th day, a saline laxative should be administered.

Preparation of oxygen cocktails and foams—mixtures of oxygen with food products, juices, or herbal infusions.

Children

The drug can be used in pediatric practice.

Overdose

In case of overdose, nausea, vomiting, and seizures may occur. Treatment is symptomatic.

Side effects.

In individual patients, individual increased sensitivity to oxygen and its mixtures, dizziness, nausea, increased dryness of mucous membranes, their irritation, cough may occur.

If any adverse events occur, consult a doctor.

Shelf life.

1.5 years.

Storage conditions.

Store in a place protected from direct sunlight and atmospheric precipitation at a temperature not exceeding +30 °C.

Avoid contact with oils; prevent dropping and impact on cylinders.

Packaging.

In compressed gas cylinders with a capacity of 1.5 l, or 2 l, or 3 l, or 4 l, or 5 l, or 10 l, or 40 l, or 50 l, or from cryogenic gasifiers.

Prescription status.

By prescription only.

Manufacturer.

Limited Liability Company "Firma "Kriogenservis""

Manufacturer's address and place of business:

29-K, Kyivska Street, Petrivske village, Kyiv-Sviatoshyn district, Kyiv region, 08132, Ukraine