Oxygen medicinal gaseous

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT MEDICAL OXYGEN GASEOUS (OXYGEN MEDICAL GAS)

Composition:

Active substance: oxygen.

Oxygen content not less than 99.5%.

Pharmaceutical form. Gas.

Main physico-chemical properties: colorless gas, odorless and tasteless, supports combustion more vigorously than air. Slightly soluble in water (approximately 1:43). Dissolves in 3.6 volumes of 95% ethyl alcohol. Strong oxidizing agent.

Pharmacotherapeutic group. Medical gases.

ATC code V03A N01.

Pharmacological properties.

Pharmacodynamics.

Oxygen belongs to the group of drugs known as anti-hypoxants and antioxidants. It has the ability to bind with blood hemoglobin in the lungs and, in a complex compound with heme, is transported to the body's cells. Oxygen is a strong oxidizing agent and an essential element in the metabolic transformations of carbohydrates, proteins, and fats into energy substances required to sustain vital functions of the organism.

Pharmacokinetics.

In the human body, oxygen diffuses through lung tissue into the blood, where it binds to hemoglobin in erythrocytes and partially dissolves in blood plasma. Subsequently, oxygen is transported to body tissues, where it diffuses into the tissue interstitial fluid. The final stage of respiration is the utilization of oxygen in biological oxidation processes and the generation of cellular energy, followed by a series of transformations leading to its elimination via the lungs in the form of carbon dioxide (CO₂).

Clinical characteristics.

Indications.

Conditions accompanied by hypoxia:

Respiratory organs:

• pneumonia;
• pulmonary edema;
• bronchial asthma;
• pneumosclerosis.

Cardiovascular system:

• heart failure;
• coronary insufficiency.

Poisonings:

• carbon monoxide;
• cyanide;
• suffocating gases.

During general anesthesia in combination with inhalation anesthetics; in the postoperative period.

Preparation of oxygen cocktails and foams.

Infectious diseases: ascariasis and trichocephalosis.

Contraindications.

For hyperbaric oxygenation, contraindications include acute respiratory diseases, history of epileptiform seizures, impaired patency of auditory tubes and canals connecting the paranasal sinuses, presence of lung cavities, bronchopleural fistulas, severe forms of arterial hypertension, neoplasms, and increased individual sensitivity to oxygen.

For deworming with oxygen, contraindications include gastric and duodenal peptic ulcers, tumors, and acute inflammatory diseases of the gastrointestinal tract.

Interaction with other medicinal products and other types of interactions.

Nitrates, beta-blockers, calcium ion antagonists, and nootropics promote more economical tissue utilization of oxygen, improve its utilization, and thereby reduce hypoxia and increase the body's resistance to oxygen deficiency.

Usage instructions.

Do not use in women during menstruation.

It is recommended to use with moisturizers.

Use during pregnancy or breastfeeding.

Do not use during pregnancy for longer than 5 months.

Breastfeeding should be discontinued during the period of drug use.

Ability to affect reaction speed when driving or operating machinery.

Does not affect.

Administration and Dosage

In hospital settings, oxygen can be administered via inhalation using special rubber or plastic masks directly connected to steel cylinders containing oxygen.

In outpatient practice and at home, special rubber or plastic containers (bags) filled with oxygen or its mixture can be used.

For hyperbaric oxygenation, i.e. delivery of oxygen under increased pressure, special ventilated chambers, so-called hyperbaric chambers (barochambers), are used, where oxygen is administered both by inhalation and through mucous membranes and skin.

Oxygen is most commonly administered by inhalation as a mixture with air at a concentration of 40–60% at a flow rate of 4–5 liters per minute. A mixture called "carbogen," consisting of 95% oxygen and 5% carbon dioxide, may also be used. The mixture should usually be administered humidified.

During hyperbaric oxygenation, oxygen is delivered under pressure of 1.2–2 atm. For therapeutic purposes, 8–10 sessions are typically conducted.

For the treatment of ascariasis, oxygen is administered into the stomach through a thin gastric or duodenal tube. Insertion of the tube through the nose is preferred. Oxygen is administered for 2 consecutive days, in the morning, on an empty stomach or 4 hours after eating. For children under 10 years of age, administer 100 mL of oxygen per year of life; for children aged 10–12 years, 1000–1100 mL; for 13–14 years, 1250 mL; and for those aged 15 years and older, 1250–1500 mL. Administer slowly in portions of 100–200–250 mL with intervals of 1–2 minutes. The total volume should be administered over no less than 15 minutes. After the procedure, the patient must remain in a lying position for at least 2 hours.

For the treatment of trichocephalosis, perform a cleansing enema and, after 1 hour, with the patient lying on their side, insert a catheter (or a rubber enema tip) into the rectum to a depth of 25–30 cm (beyond the internal sphincter). Through the catheter, oxygen is slowly injected in small portions (200–250 mL) with intervals of 2–3 minutes. For children under 10 years of age, administer 100 mL of oxygen per year of life; for children aged 10–12 years, 1000–1100 mL; for 13–14 years, 1250 mL; and for those aged 15 years and older, 1250–1500 mL. After completion of the procedure, the patient should lie on their back for 2 hours. Oxygen therapy should be conducted for 5–7 consecutive days, and on the 6th or 7th day, administer a saline laxative.

Preparation of oxygen cocktails, foams—mixtures of oxygen with food products, juices, and herbal infusions.

Children

The drug can be used in pediatric practice.

Overdose

In case of overdose, nausea, vomiting, and seizures may occur. Treatment is symptomatic.

Side effects.

In individual cases, increased sensitivity to oxygen and its mixtures, dizziness, nausea, increased dryness of mucous membranes, their irritation, coughing may occur.

Shelf life.

1.5 years.

Storage conditions.

Store in a place protected from direct sunlight, at a temperature not exceeding 50 °C. Avoid contact with open flame and sources of heat. Do not allow contact with oils. Do not drop.

Packaging.

40 L in steel cylinders, or in type GHK gasifiers, or 160 L, 180 L in insulated gas cylinders.

Prescription category.

By prescription only.

Manufacturer.

LLC Firm "Lvivkysen".

Manufacturer's location and address of business activity.

227 Lychakivska St., Lviv, Ukraine.