Oxygen medicinal gaseous

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT MEDICAL OXYGEN GASEOUS

Composition:

Active substance: oxygen;

contains not less than 99.5% oxygen.

Pharmaceutical form. Gas.

Main physicochemical properties: colorless, odorless and tasteless gas, supports combustion more actively than air, strong oxidizing agent.

Pharmacotherapeutic group.

Medical gases.

ATC code V03A N01.

Pharmacological properties.

Pharmacodynamics

Oxygen belongs to the group of drugs known as anti-hypoxants and antioxidants. It has the ability to bind with blood hemoglobin in the lungs and, in a complex compound with heme, to be transported to the body's cells. Oxygen is a strong oxidizing agent and an essential component in the metabolic transformations of carbohydrates, proteins, and fats into energy substances required to sustain vital functions of the organism.

Pharmacokinetics

In the human body, oxygen diffuses through the lung tissue into the blood, where it binds to hemoglobin in erythrocytes and partially dissolves in plasma. Subsequently, oxygen is transported to body tissues, where it diffuses into the tissue interstitial fluid. The final stage of respiration is the utilization of oxygen in biological oxidation processes and the generation of energy within cells; following several transformations, it is then excreted via the lungs in the bound form of carbon dioxide (CO2).

Clinical Characteristics.

Indications.

Diseases accompanied by hypoxia:

respiratory system:

• pneumonia;
• pulmonary edema;
• bronchial asthma;
• pneumosclerosis;

cardiovascular system:

• heart failure;
• coronary insufficiency.

Poisonings:

• carbon monoxide;
• cyanide;
• suffocating gases.

During general anesthesia
in combination with inhalation anesthetics; in the postoperative period.

Preparation of oxygen cocktails and foams.

Contraindications.

For hyperbaric oxygenation, contraindications include acute respiratory diseases, history of epileptiform seizures, impaired patency of auditory tubes and canals connecting the paranasal sinuses, presence of lung cavities, bronchopleural fistulas, severe forms of arterial hypertension, neoplasms, and increased individual sensitivity to oxygen.

Menstrual period, pregnancy over 5 months.

Interaction with other medicinal products and other types of interactions.

Nitrates, beta-blockers, calcium ion antagonists, and nootropics promote more efficient tissue utilization of oxygen, improve oxygen utilization, thereby reducing hypoxia and increasing the body's resistance to oxygen deficiency.

Special precautions for use.

It is recommended to use with moisturizing agents.

Do not use during menstrual period.

Use during pregnancy or breastfeeding.

Not recommended during pregnancy longer than 5 months.

Breastfeeding should be discontinued during the period of using the medicinal product.

Ability to affect reaction speed when driving or operating machinery.

Due to possible dizziness, refrain from driving vehicles or performing tasks requiring increased attention and rapid reaction.

Administration and Dosage.

In hospital settings, oxygen is most commonly administered via inhalation through special rubber or plastic masks connected directly to steel cylinders containing oxygen.

In outpatient practice and at home, special rubber or plastic containers (bags), filled with oxygen or its mixture, are more frequently used.

For hyperbaric oxygenation, i.e., delivery of oxygen under increased pressure, special ventilated chambers, so-called hyperbaric chambers (barochambers), are used, where oxygen is supplied both by inhalation and through mucous membranes and skin.

Oxygen is most commonly administered by inhalation as a mixture with air at a concentration of 40–60%, at a flow rate of 4–5 liters per minute. A mixture called "carbogen," consisting of 95% oxygen and 5% carbon dioxide, is also used. The mixture is usually administered humidified.

During hyperbaric oxygenation, oxygen is delivered under pressure of 1.2–2 atm. Therapeutically, 8–10 sessions are performed.

Preparation of oxygen cocktails and foams: oxygen is mixed with food products, juices, and herbal infusions.

Children.

Administered according to the instructions in the section "Administration and Dosage."

Overdose.

In case of overdose, nausea, vomiting, and seizures may occur. Treatment is symptomatic.

Side effects.

In individual patients, individual hypersensitivity to oxygen and its mixtures, dizziness, nausea, increased dryness of mucous membranes, their irritation, cough may occur.

Reporting of suspected adverse reactions after authorization of the medicinal product is important. This allows continued monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals should report any suspected adverse reactions through the national pharmacovigilance system.

Shelf life.
18 months.

The medicinal product must not be used after the expiry date stated on the packaging.

Storage conditions.

Store in a place inaccessible to children, protected from direct sunlight, at a temperature not exceeding 50 °C. Avoid contact with open flame and sources of heat. Do not allow contact with oils. Do not drop or throw.

Packaging.
In 40 L and 50 L steel cylinders.

Prescription status.
Prescription only.

Manufacturer.

State Enterprise "Scientific and Production Complex for Gas Turbine Building "Zorya"–"Mashproekt".

Manufacturer's address and place of business.
42a, Bohoyavlenskoye Avenue, Mykolaiv, 54018, Ukraine.