Oxygen medicinal gaseous

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT MEDICAL OXYGEN GASEOUS

Composition:

Active substance: oxygen;

contains not less than 99.5% oxygen.

Pharmaceutical form. Gas.

Main physicochemical properties: colorless, odorless and tasteless gas; supports combustion more actively than air; strong oxidizing agent.

Pharmacotherapeutic group. Medical gases.

ATC code V03A N01.

Pharmacological properties.

Pharmacodynamics.

Oxygen belongs to the group of anti-hypoxants and antioxidants. It has the ability to bind with blood hemoglobin in the lungs and, as a complex compound with heme, is transported to the body's cells. It is a strong oxidizing agent and an essential element in metabolic transformations of carbohydrates, proteins, and fats into energy material required to sustain vital functions of the organism.

Pharmacokinetics.

In the human body, oxygen diffuses through lung tissue into the blood, binding to hemoglobin in erythrocytes and partially dissolving in plasma. Subsequently, oxygen is transported to body tissues, where it diffuses into the tissue interstitial fluid. The final stage of respiration is the utilization of oxygen in biological oxidation processes and the generation of energy within cells; following a series of transformations, it is then excreted by the lungs in the form of carbon dioxide (CO2).

Clinical characteristics.

Indications.

Conditions associated with hypoxia:

respiratory organs:

• pneumonia;
• pulmonary edema;
• bronchial asthma;
• pneumosclerosis;

cardiovascular system:

• heart failure;
• coronary insufficiency.

Poisonings:

• carbon monoxide;
• hydrocyanic acid;
• choking gases.

During general anesthesia in combination with inhalation anesthetics; postoperative period.

Preparation of oxygen cocktails, foams.

Infectious diseases: ascariasis and trichuriasis.

Contraindications.

For hyperbaric oxygenation, contraindications include acute respiratory diseases, history of epileptiform seizures, impaired patency of auditory tubes and canals connecting the paranasal sinuses, presence of lung cavities, bronchopleural fistulas, severe forms of arterial hypertension, neoplasms, and increased individual sensitivity to oxygen.

For oxygen-based deworming, contraindications include gastric and duodenal ulcers, tumors, and acute inflammatory diseases of the gastrointestinal tract.

Interaction with other medicinal products and other types of interactions.

Nitrates – adrenoblockers, calcium ion antagonists, nootropics promote more efficient tissue utilization of oxygen, improve its utilization, and thereby reduce hypoxia and increase the body's resistance to oxygen deficiency.

Special precautions for use

It is recommended to use with moisturizing agents.

Do not use during menstrual period.

Use during pregnancy or breastfeeding

Do not use during pregnancy for longer than 5 months.

Breastfeeding should be discontinued for the duration of treatment with this medicinal product.

Ability to affect reaction rate when driving or operating machinery

Due to possible dizziness, avoid driving or performing tasks that require increased attention and quick reaction.

Administration and Dosage

In hospital settings, oxygen is most commonly administered via inhalation through special rubber or plastic masks connected directly to steel cylinders containing oxygen.

In outpatient practice and at home, special rubber or plastic containers (bags), filled with oxygen or its mixture, are more frequently used.

For hyperbaric oxygenation, i.e. delivery of oxygen under increased pressure, special ventilated chambers, so-called hyperbaric chambers (barochambers), are used, where oxygen is administered both by inhalation and through mucous membranes and skin.

Most commonly, oxygen is administered by inhalation as a mixture with air at a concentration of 40–60%, at a flow rate of 4–5 liters per minute. A mixture known as "carbogen," consisting of 95% oxygen and 5% carbon dioxide, is also used. The mixture is usually humidified before administration.

During hyperbaric oxygenation, oxygen is delivered under pressure of 1.2–2 atm. Therapeutically, 8–10 sessions are typically conducted.

For the treatment of ascariasis, oxygen is introduced into the stomach via a thin gastric or duodenal tube. The tube should preferably be inserted through the nose. Oxygen is administered for 2 consecutive days, in the morning on an empty stomach or 4 hours after a meal. For children under 10 years of age, 100 mL of oxygen per year of life is administered; for children aged 10–12 years, 1000–1100 mL; for 13–14 years, 1250 mL; and from 15 years onward, 1250–1500 mL. Oxygen is introduced slowly, in portions of 100–200–250 mL, with intervals of 1–2 minutes. The total volume should be administered over no less than 15 minutes. After the procedure, the patient must remain in a lying position for at least 2 hours.

For the treatment of trichocephalosis (whipworm infection), the patient is first given a cleansing enema. One hour later, with the patient lying on their side, a catheter (or a rubber enema tip) is inserted into the rectum to a depth of 25–30 cm (beyond the internal sphincter). Oxygen is then slowly insufflated in small portions of 200–250 mL, with intervals of 2–3 minutes. For children under 10 years of age, 100 mL of oxygen per year of life is administered; for children aged 10–12 years, 1000–1100 mL; for 13–14 years, 1250 mL; and from 15 years onward, 1250–1500 mL. After completion of the procedure, the patient must lie on their back for 2 hours. Oxygen therapy is conducted daily for 5–7 consecutive days; on day 6 or 7, a saline laxative is administered.

Preparation of oxygen cocktails and foams: oxygen is mixed with food products, juices, or herbal infusions.

Children. Oxygen may be used.

Overdose

In case of overdose, symptoms such as nausea, vomiting, and convulsions may occur. Treatment is symptomatic.

Side effects.

In individual patients, individual increased sensitivity to oxygen and its mixtures, dizziness, nausea, increased dryness of mucous membranes, their irritation, coughing may occur.

Shelf life. 3 years.

Do not use after the expiry date stated on the packaging.

Storage conditions.

Gaseous medicinal oxygen in steel cylinders with a volume of 1,l, 2,l, 3,l, 4,l, 5,l, 6,l, 7,l, 8,l, 9,l, 10,l, 12,l, 14,l, 40,l, 50,l and in cryogenic vaporizers should be stored in warehouses or under shelters, in a place inaccessible to children and protected from direct sunlight.

Gaseous medicinal oxygen in steel cylinders with a volume of 1,l, 2,l, 3,l, 4,l, 5,l, 6,l, 7,l, 8,l, 9,l, 10,l, 12,l, 14,l, 40,l, 50,l and in cryogenic vaporizers must be stored at temperatures ranging from minus 50 °C to plus 50 °C.

Storage and transportation at temperatures above plus 50 °C is not permitted.

Contact with open flame and heat sources must be avoided.

Packaging.

Gas in steel cylinders with a volume of 1,l, 2,l, 3,l, 4,l, 5,l, 6,l, 7,l, 8,l, 9,l, 10,l, 12,l, 14,l, 40,l, 50,l and in cryogenic vaporizers.

Prescription status. Prescription only.

Manufacturer.

LLC "Sektor Hazu".

Manufacturer's location and address of business activity.

9B Kolomyiska Street, Chernivtsi, 58007, Ukraine.