Chest drops for cough

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT COUGH RELIEF DROPS

Composition:

Active substances: 1 ml of the liquid contains extract of licorice root, thick (Glycyrrhizae radix extractum spissum) (2.75:1) (extraction solvent – purified water) – 207 mg; anise oil – 3.4 mg; concentrated ammonia solution – 13.8 mg;

Excipients: ethanol 90%, purified water.

Pharmaceutical form. Liquid.

Main physicochemical properties: brown-colored liquid with the odor of ammonia and anise oil.

Sediment formation may occur during storage.

Pharmacotherapeutic group.

Medicinal products used for cough and colds. Expectorants.

ATC code R05C A10.

Pharmacological properties.

Pharmacodynamics.

A combination medicinal product with expectorant and anti-inflammatory effects. The components contained in the preparation stimulate secretory function of the mucous membranes of the upper respiratory tract, liquefy sputum, and facilitate its expectoration. Chest drops alleviate dry, non-productive cough.

Pharmacokinetics.

Not studied.

Clinical characteristics.

Indications.

In complex treatment of acute and chronic respiratory tract diseases accompanied by difficult expectoration.

Contraindications.

Liver and kidney function disorders, arterial hypertension, hypokalemia, severe obesity. Hypersensitivity to the components of the drug.

Interaction with other medicinal products and other forms of interactions.

Hypokalemia (due to excessive use of licorice root) may be intensified when used concomitantly with cardiac glycosides, antiarrhythmic agents, and drugs affecting cardiac rhythm (e.g., quinidine). When used in combination with drugs that may cause hypokalemia (thiazide and loop diuretics, adrenocorticosteroids, and laxatives), electrolyte imbalance may occur; therefore, prolonged use of the drug together with the above-mentioned medicinal products is not recommended.

Drugs containing thermopsis, althaea, and other expectorants enhance the therapeutic effect of the drug.

It is not advisable to take simultaneously with antibiotics and nitrofuran derivatives.

Simultaneous use of other medicinal products containing ethanol should be avoided.

When using any other medicinal products concomitantly, consult a physician.

Special precautions for use.

Prolonged use of the medication is not recommended, as it may lead to disturbances in water and electrolyte balance and cause edema.

A sediment may form during storage of the medicinal product; however, this does not reduce its efficacy. The vial should be shaken well before use.

This medicinal product contains no less than 14% ethanol (alcohol), i.e., 69–138 mg/dose (20–40 drops), equivalent to 1.8–3.6 ml of beer or 0.7–1.4 ml of wine per dose.
Harmful for patients suffering from alcoholism. Caution is advised when administering to pregnant and breastfeeding women, children, patients with liver disorders, and patients with epilepsy.

Alcohol consumption should be avoided during treatment with this medication.

The medicinal product contains ethanol! Prolonged use of the medication is not recommended.

Use during pregnancy or breastfeeding.

The medicinal product is contraindicated in women during pregnancy or breastfeeding, as it contains ethyl alcohol and a dense extract of licorice root (the latter increases estrogen levels, thereby disrupting hormonal balance). It stimulates uterine activity. In high doses, it has shown embryotoxic effects in experimental studies.

If use of the medication is necessary in breastfeeding women, breastfeeding should be discontinued for the duration of treatment.

Ability to affect reaction speed when driving or operating machinery.

During treatment, patients should refrain from driving vehicles or operating machinery requiring high attention and quick reaction.

Method of Administration and Dosage.

Take orally, 20–40 drops per dose, 3–4 times daily. The medication should be taken 30 minutes before or 1 hour after meals, previously diluted in a small amount of liquid. The duration of treatment is determined individually by a physician.

Children.

Since the formulation contains ethyl alcohol, it should not be administered to children under 12 years of age.

Overdose.

In case of overdose, an increase in the manifestations of adverse reactions is possible; prolonged use of licorice preparations in excessive doses may lead to the development of hypokalemia; in individual cases, hypokalemic myopathy and myoglobinuria are possible. Overdose cases have not been reported to date.

Side effects.

Immune system: allergic reactions, including hyperemia, rash, itching, swelling, bronchospasm.

Gastrointestinal tract: nausea, vomiting.

Nervous system disorders: occasionally transient excitation followed by depression of the central nervous system, hypokalemic myopathy.

Metabolic and nutritional disorders: in excessive doses may cause disturbances in water-electrolyte balance, leading to edema, development of hypokalemia, myoglobinuria.

Cardiac disorders: in individual cases, increased arterial pressure is possible.

If any adverse events occur, the patient must discontinue the use of the medication and consult a physician.

Shelf life. 3 years.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.

Packaging.

25 ml in bottles.

Availability. Over-the-counter.

Manufacturer/Applicant.

LLC "Ternopharm".

Manufacturer's/Holder's address and place of business activity.

LLC "Ternopharm".

46010, Ternopil, Fabrychna St., 4, Ukraine.

Tel./Fax: (0352) 521-444, www.ternopharm.com.ua.