Imolast: detailed information

Package leaflet: Information for the user

Imolast 50 micrograms/ml and 5 mg/ml eye drops, solution in single-dose container

Latanoprost + Timolol
Equivalent medicine
Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

Keep this leaflet. You may need to read it again.
If you have any questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not pass it on to others, even if their symptoms are the same as yours, as it may be harmful.
If you experience any side effects, including those not listed in this leaflet, talk to your doctor, pharmacist, or nurse. (See section 4).

Contents of this leaflet

What Imolast is and what it is used for
What you need to know before using Imolast
How to use Imolast
Possible side effects
How to store Imolast
Contents of the pack and other information

1. What Imolast is and what it is used for

Imolast contains two medicines: latanoprost and timolol. Latanoprost belongs to a group of medicines known as prostaglandin analogues. Timolol belongs to a group of medicines known as beta-blockers.
Latanoprost works by increasing the natural outflow of fluid from inside the eye into the bloodstream.
Timolol works by reducing the production of fluid inside the eye.
Imolast is used to reduce pressure inside the eye when affected by conditions known as open-angle glaucoma or ocular hypertension. Both of these conditions are associated with increased eye pressure, which may eventually impair vision.
Your doctor usually prescribes this medicine when other medicines have not worked adequately.

2. What you need to know before using Imolast

Imolast can be used in adult women and men (including the elderly), but it is not recommended for individuals under 18 years of age.

Do not use Imolast

If you are allergic (hypersensitive) to either of the two active substances in Imolast (latanoprost or timololo), to beta-blockers, or to any of the other components of Imolast (listed in section 6).
If you have or have previously had respiratory problems such as asthma, or severe chronic obstructive pulmonary disease (COPD) (a serious lung disease that may cause wheezing, breathing difficulties and/or persistent cough).
If you have severe heart problems or heart rhythm disorders.

Warnings and precautions

Tell your doctor or pharmacist before using Imolast if you have or have previously had:

Coronary heart disease (symptoms may include chest pain or tightness, shortness of breath or a feeling of suffocation), heart failure, low blood pressure
Heart rhythm disorders such as slow heartbeat
Respiratory problems, asthma or chronic obstructive lung disease
A disease associated with poor blood circulation (such as Raynaud’s disease or Raynaud’s syndrome)
Diabetes, as timolol may mask the signs and symptoms of low blood sugar
Overactive thyroid gland, as timolol may mask its signs and symptoms
Are about to undergo any eye surgery (including cataract surgery), or if you have previously undergone any eye surgery
Eye problems (such as eye pain, eye irritation, eye inflammation or blurred vision)
Dry eye syndrome
Wear contact lenses. You may still use Imolast, following the instructions for contact lens wearers provided in section 3
Angina (particularly a type of angina known as Prinzmetal's angina)
Severe allergic reactions that usually require hospital treatment
A viral eye infection caused by the herpes simplex virus (HSV). Before undergoing surgery, inform your doctor that you are using Imolast, as timolol may alter the effects of certain medicines used during anesthesia.

Other medicines and Imolast

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including eye drops and over-the-counter medicines.
The effect of Imolast may be altered, or Imolast may alter the effect of other medicines you are taking, including other eye drops for glaucoma. Inform your doctor if you are taking or intend to take medicines to lower blood pressure, for heart conditions, or for diabetes treatment.
In particular, inform your doctor or pharmacist if you are taking a medicine belonging to the following classes:

Prostaglandins, prostaglandin analogues or prostaglandin derivatives
Beta-blockers
Epinephrine
Medicines used to treat high blood pressure such as oral calcium channel blockers, guanethidine, antiarrhythmics, digitalis glycosides or parasympathomimetics
Quinidine (used to treat heart conditions and certain types of malaria)
Known antidepressants such as fluoxetine and paroxetine

Imolast with food and drink

Normal meals, food or drink do not affect how or when to take Imolast.
For athletes: Using this medicine without therapeutic need constitutes doping and may result in a positive anti-doping test.
Pregnancy, breastfeeding and fertility

Pregnancy
Do not use Imolast if you are pregnant unless your doctor considers it necessary. Inform your doctor immediately before taking this medicine if you are pregnant, think you may be pregnant, or are planning a pregnancy.

Breastfeeding
Do not use Imolast if you are breastfeeding. Imolast may pass into your milk. Ask your doctor for advice before taking any medicine while breastfeeding.

Fertility
Animal studies have shown that latanoprost and timolol do not affect male or female fertility.

Driving and using machines
When using Imolast, you may experience temporary blurred vision. If this occurs, do not drive or operate machinery until your vision is clear again.

Imolast contains phosphate buffer
This medicine contains 9.28 mg of phosphate buffer per ml.
If you have severe damage to the outermost transparent layer of the eye (the cornea), phosphates may, in very rare cases, cause calcium deposits leading to cloudy spots on the cornea during treatment.

3. How to use Imolast

Use this medicine exactly as instructed by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist.
The recommended dose for adults (including elderly patients) is one drop once daily in the eye(s) to be treated.
Do not use Imolast more than once a day, as treatment efficacy may be reduced if the medicine is administered more frequently.
Use Imolast as directed by your doctor, until your doctor tells you to stop treatment.
If you are using Imolast, your doctor may require additional monitoring of your heart and circulation.

Contact lens wearers
If you wear contact lenses, you must remove them before applying Imolast. After applying Imolast, wait 15 minutes before reinserting your contact lenses.

Instructions for use

Wash your hands and sit or stand comfortably.
Remove one single-dose container from the strip and unscrew the cap with a gentle twist.
Gently pull down with one finger the lower eyelid of the eye to be treated.
Hold the tip of the container close to the eye without touching it (it is very important not to let the tip of the container touch the eye or eyelid).
Apply slight pressure to the container so that a single drop falls into the eye, then release the lower eyelid.
After using Imolast, press gently with one finger on the inner corner of the treated eye. Keep your eyes closed for one minute.
Repeat the procedure in the other eye, if your doctor has instructed you to do so.
Discard the container and any remaining contents after use.

If you use Imolast with another eye drop
Wait at least 5 minutes between administering Imolast and any other eye drop.

If you use more Imolast than you should
If you put too many drops into your eyes, you may experience mild irritation, tearing, and eye redness. These effects are temporary, but if you are concerned, contact your doctor for advice.

If you swallow Imolast
Contact your doctor if you accidentally swallow Imolast. If you swallow a large amount of Imolast, you may feel unwell, have stomach pain, feel tired, flushed, dizzy, and begin to sweat.

If you forget to use Imolast
Continue with your usual dose at the regular time. Do not use a double dose to make up for the forgotten dose. If you have any doubts, consult your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
You can generally continue using the drops unless the side effects are severe. If you are concerned, consult your doctor or pharmacist. Do not stop using Imolast without first discussing it with your doctor.

Listed below are the known side effects associated with the use of Imolast. The most important side effect is the possible gradual and permanent change in eye colour. Imolast may also cause serious changes in heart function. If you experience any change in your heartbeat or cardiac function, you should contact your doctor and inform them that you are taking Imolast.

The known side effects associated with the use of Imolast are:
Very common (may affect more than 1 in 10 people):

Gradual change in eye colour due to increased brown pigment in the coloured part of the eye (iris). This change is more likely if your eyes are of mixed colour (blue-brown, grey-brown, yellow-brown or green-brown) rather than uniform colour (blue, grey, green or brown). Changes in eye colour may occur after several years. The colour change may be permanent and may be more noticeable if you use Imolast in only one eye. There appear to be no associated problems with this change in eye colour. After stopping treatment with Imolast, no further change in eye colour has been observed.

Common (may affect up to 1 in 10 people):

Eye irritation (burning sensation, gritty feeling, itching, stinging pain or foreign body sensation in the eyes) and eye pain.

Uncommon (may affect up to 1 in 100 people):

Headache.
Red eyes, eye infection (conjunctivitis), blurred vision, watery eyes, eyelid inflammation, eye surface irritation or abrasion.
Skin rash or itching.

Other side effects
Like other eye medicines, Imolast (latanoprost and timolol) is absorbed into the bloodstream. The incidence of adverse reactions after using eye drops is lower than when medicines are taken orally or by injection. Although not specifically associated with the use of Imolast, the following side effects have been observed with the use of the medicines contained in Imolast (latanoprost and timololo). These effects may therefore occur when using Imolast. The listed side effects include reactions observed within the class of beta-blockers (e.g., timololo) when used to treat eye disorders:

Development of a viral eye infection caused by herpes simplex virus (HSV).
Generalised allergic reactions including swelling under the skin that may occur in areas such as the face and limbs and may block the airways causing difficulty in swallowing and breathing, urticaria or itchy rash, localised and generalised rash, itching, sudden severe life-threatening allergic reaction.
Low blood glucose levels.
Dizziness.
Difficulty sleeping (insomnia), depression, nightmares, memory loss, hallucinations.
Fainting, heart attack, reduced blood supply to the brain, worsening of signs and symptoms of myasthenia gravis (a muscle disorder), unusual sensations such as tingling, and headache.
Swelling at the back of the eye (macular edema), fluid-filled cyst within the coloured part of the eye (iris cyst), light sensitivity (photophobia), sunken eyes (deepening of the eyelid crease).
Signs and symptoms of eye irritation (such as burning, stinging, itching, tearing, redness), eyelid inflammation, corneal inflammation, blurred vision, and detachment of the layer beneath the retina containing blood vessels following filtering surgery, which may cause visual disturbances; decreased corneal sensitivity, dry eyes, corneal erosion (damage to the front layer of the eyeball), drooping of the upper eyelid (causing the eye to be half-closed), double vision.
Darkening of the skin around the eyes, changes in eyelids and eyelashes around the eye (increased number, length, thickness, pigmentation), changes in the direction of eyelash growth, swelling around the eye, swelling of the coloured part of the eye (iritis/uveitis), scarring of the eye surface.
Ringing or buzzing in the ears (tinnitus).
Angina, worsening of angina in patients already suffering from heart disease.
Slow heartbeat, chest pain, palpitations (awareness of heartbeat), oedema (fluid accumulation), changes in heart rhythm or rate, congestive heart failure (heart disease associated with shortness of breath and swelling of the feet and legs due to fluid accumulation), a type of heart rhythm disorder, heart attack, heart failure.
Low blood pressure, poor blood circulation causing numbness and paleness in fingers of hands and feet, cold hands and feet.
Shortness of breath, narrowing of the airways in the lungs (mainly in patients with pre-existing lung disease), difficulty breathing, cough, asthma, worsening of asthma.
Taste disturbances, nausea, vomiting, indigestion, diarrhoea, dry mouth, abdominal pain.
Hair loss, skin rash appearing as silvery-white patches (psoriasiform rash) or worsening of psoriasis, skin rash.
Joint pain, muscle pain not caused by physical exercise, muscle weakness, fatigue.
Sexual dysfunction, decreased libido.

In very rare cases, some patients with severe damage to the transparent layer at the front of the eye (the cornea) have developed cloudy spots on the cornea due to calcium deposits during treatment.

Reporting of side effects
If you experience any side effect, including those not listed in this leaflet, talk to your doctor or pharmacist. You can also report side effects directly via the national reporting system at: https://www.aifa.gov.it/content/segnalazioni-reazioni-avverse . By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Imolast

Keep this medicine out of sight and reach of children.
Do not use this medicine after the expiry date stated on the outer carton after "Exp."
The expiry date refers to the last day of the month.
Store in a refrigerator (2°C - 8°C), in the original packaging to protect the medicine from light.
After first opening the aluminium sachet: store at a temperature not exceeding 25°C and use within 7 days; after this period, the containers must be discarded.
The single-dose medicine must be used immediately after opening; any remaining medicine must be discarded.
Do not dispose of medicines via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer in use. This will help protect the environment.

6. Pack contents and other information

What Imolast contains
In 1 ml of solution:

The active substances are: Latanoprost 50 micrograms and Timolol 5 milligrams (equivalent to timolol maleate 6.83 milligrams).
The other components are: sodium chloride, sodium dihydrogen phosphate monohydrate, anhydrous disodium phosphate, water for injections.

Description of the appearance of Imolast and contents of the pack
Single-dose container made of polyethylene. Pack containing 30 single-dose containers of 0.1 ml.
Marketing Authorization Holder
Genetic S.p.A., Via Della Monica n. 26, 84083 Castel San Giorgio (SA)
Manufacturer
Genetic S.p.A., Contrada Canfora, 84084 Fisciano (SA)
This leaflet was last updated on

Package leaflet: information for the user

Imolast 50 micrograms/ml and 5 mg/ml eye drops, solution

Latanoprost + Timolol
Generic medicine
Please read this leaflet carefully before using this medicine because it contains important information for you.

Keep this leaflet. You may need to read it again.
If you have any questions, ask your doctor or pharmacist.
This medicine has been prescribed for you only. Do not give it to others, even if their symptoms are the same as yours, because it could be harmful.
If you experience any adverse reactions, including those not listed in this leaflet, contact your doctor, pharmacist, or nurse. (See section 4).

Contents of this leaflet

What Imolast is and what it is used for
What you need to know before using Imolast
How to use Imolast
Possible side effects
How to store Imolast
Contents of the pack and other information

1. What Imolast is and what it is used for

Imolast contains two medicines: latanoprost and timolol. Latanoprost belongs to a class of medicines known
as prostaglandin analogues. Timolol belongs to a class of medicines known as beta-blockers.
Latanoprost works by increasing the natural outflow of fluid from inside the eye into the bloodstream.
Timolol works by reducing the production of fluid inside the eye.
Imolast is used to reduce pressure inside the eye when affected by conditions known as
open-angle glaucoma or ocular hypertension. Both of these conditions are associated with elevated
intraocular pressure, which may eventually impair vision.
Your doctor usually prescribes this medicine when other treatments have not adequately worked.

2. What you need to know before using Imolast

Imolast can be used in adult women and men (including the elderly), but it is not recommended for individuals under 18 years of age.
Do not use Imolast

If you are allergic (hypersensitive) to either of the two active substances in Imolast (latanoprost or timolol), to beta-blockers, or to any of the other components of Imolast (listed in section 6).
If you currently have or have previously had respiratory problems such as asthma, severe chronic obstructive pulmonary disease (a serious lung disease that may cause wheezing, difficulty breathing, and/or persistent cough).
If you have severe heart problems or cardiac rhythm disorders.

Warnings and precautions
Tell your doctor or pharmacist before using Imolast if you currently have or have previously had:

Coronary heart disease (symptoms may include chest pain or tightness, shortness of breath, or a feeling of suffocation), heart failure, low blood pressure
Heart rhythm disorders such as slow heart rate
Respiratory problems, asthma, or chronic obstructive pulmonary disease
A disease associated with poor blood circulation (such as Raynaud's disease or Raynaud's syndrome)
Diabetes, as timolol may mask the signs and symptoms of low blood sugar
Overactive thyroid gland, as timolol may mask its signs and symptoms
Are scheduled to undergo any eye surgery (including cataract surgery), or have previously undergone any eye surgery
Eye problems (such as eye pain, eye irritation, eye inflammation, or blurred vision)
Known dry eye syndrome
Wear contact lenses. You may still use Imolast, following the instructions for contact lens wearers provided in section 3
Known angina (particularly a type of angina called Prinzmetal's angina)
Known severe allergic reactions that usually require hospital treatment
Had or currently have a viral eye infection caused by the herpes simplex virus (HSV). Before undergoing surgery, inform your doctor that you are using Imolast, as timolol may alter the effects of certain medications used during anesthesia.

Other medicines and Imolast
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including eye drops and over-the-counter medicines.
The effect of Imolast may be altered, or Imolast may alter the effect of other medicines you are taking, including other eye drops for glaucoma treatment. Inform your doctor if you are taking or plan to take medicines to lower blood pressure, for heart conditions, or for diabetes treatment.
In particular, inform your doctor or pharmacist if you are taking a medicine belonging to the following classes:

Prostaglandins, prostaglandin analogs, or prostaglandin derivatives
Beta-blockers
Epinephrine
Medicines used to treat high blood pressure such as oral calcium channel blockers, guanethidine, antiarrhythmics, digitalis glycosides, or parasympathomimetics
Quinidine (used to treat heart conditions and certain types of malaria)
Known antidepressants such as fluoxetine and paroxetine

Imolast with food and drink
Normal meals, food, or drinks do not affect how or when to take Imolast.
For athletes: Using this medicine without a medical need constitutes doping and may result in a positive anti-doping test.
Pregnancy, breastfeeding, and fertility
Pregnancy
Do not use Imolast if you are pregnant unless your doctor considers it necessary. Inform your doctor immediately before taking this medicine if you are pregnant, think you may be pregnant, or are planning a pregnancy.
Breastfeeding
Do not use Imolast if you are breastfeeding. Imolast may pass into your breast milk. Ask your doctor for advice before taking any medicine while breastfeeding.
Fertility
In animal studies, latanoprost and timolol have not shown any effect on male or female fertility.
Driving and using machines
When using Imolast, you may experience temporary blurred vision. If this occurs, do not drive or operate machinery until your vision is clear again.
Imolast contains benzalkonium chloride and phosphate buffer
This medicine contains 0.2 mg/ml of benzalkonium chloride per milliliter.
Benzalkonium chloride may be absorbed by soft contact lenses and may cause discoloration. Remove your contact lenses before using this medicine and wait 15 minutes before reinserting them.
Benzalkonium chloride may also cause eye irritation, particularly if you have dry eyes or corneal disorders (the clear layer at the front of the eye). If you experience unusual sensations, burning, or pain in the eye after using this medicine, speak with your doctor.
This medicine contains 9.28 mg of phosphate buffer per ml.
If you have severe damage to the outermost transparent layer of the eye (the cornea), phosphates may, in very rare cases, cause cloudy corneal deposits due to calcium accumulation during treatment.

3. How to use Imolast

Use this medicine exactly as instructed by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist.

The recommended dose for adults (including elderly patients) is one drop once daily in the affected eye(s).

Do not use Imolast more than once a day, as the effectiveness of treatment may be reduced if the medicine is administered more frequently.

Use Imolast exactly as directed by your doctor, until your doctor tells you to stop treatment.

When using Imolast, your doctor may require additional monitoring of your heart and circulation.

Contact lens wearers
If you wear contact lenses, you must remove them before applying Imolast. After applying Imolast, wait 15 minutes before reinserting your contact lenses.

Instructions for use

Wash your hands and sit or stand comfortably.
Remove the outer cap by gently twisting it off.
Gently pull down the lower eyelid of the eye to be treated with one finger.
Hold the dropper tip close to the eye without touching it (it is very important not to let the dropper tip touch the eye or eyelid).
Apply slight pressure to the bottle so that a single drop enters the eye, then release the lower eyelid.
After using Imolast, press gently with one finger on the inner corner of the treated eye. Keep your eyes closed for one minute.
Repeat the procedure in the other eye if your doctor has instructed you to do so.
Close the bottle with the protective inner cap.

If you use Imolast with another eye drop
Wait at least 5 minutes between administering Imolast and any other eye drop.

If you use more Imolast than you should
If you instil too many drops into your eyes, you may experience mild irritation, tearing, and eye redness. These effects are temporary, but if you are concerned, contact your doctor for advice.

If you swallow Imolast
Consult your doctor if you have accidentally swallowed Imolast. If you have swallowed a large amount of Imolast, you may feel unwell, experience stomach pain, feel tired, feel hot, dizzy, and begin to sweat.

If you forget to use Imolast
Continue with your next dose at the usual time and in the usual amount. Do not use a double dose to make up for the forgotten dose. If you have any doubts, consult your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody will get them.
You can generally continue using the drops unless the side effects you experience are severe. If you are concerned, speak to your doctor or pharmacist. Do not stop using Imolast without first discussing it with your doctor.

Listed below are the known side effects associated with the use of Imolast. The most important side effect is the possible gradual and permanent change in eye colour. Imolast may also cause serious changes in heart function. If you notice any changes in your heartbeat or heart function, you should contact your doctor and inform them that you are taking Imolast.

The known side effects associated with the use of Imolast are:
Very common (may affect more than 1 in 10 people):

Gradual change in eye colour due to increased brown pigment in the coloured part of the eye called the iris. This change is more likely if your eyes are of mixed colour (blue-brown, grey-brown, yellow-brown or green-brown) rather than uniform colour (blue, grey, green or brown). Any change in eye colour may occur after several years. The colour change may be permanent and may be more noticeable if you use Imolast in only one eye. There appear to be no associated problems with this change in eye colour. After stopping treatment with Imolast, no further change in eye colour has been observed.

Common (may affect up to 1 in 10 people):

Eye irritation (burning sensation, gritty feeling, itching, stinging pain or sensation of a foreign body in the eyes) and eye pain.

Uncommon (may affect up to 1 in 100 people):

Headache.
Red eyes, eye infection (conjunctivitis), blurred vision, watery eyes, eyelid inflammation, eye surface irritation or abrasion.
Skin rash or itching.

Other side effects
Like other eye medicines, Imolast (latanoprost and timolol) is absorbed into the bloodstream. The incidence of adverse reactions after using eye drops is lower than that observed when medicines are taken orally or by injection. Although not specifically associated with the use of Imolast, the following side effects have been observed with the medicines contained in Imolast (latanoprost and timololo). These effects may therefore occur when you use Imolast. The listed side effects include reactions observed with the class of beta-blockers (e.g., timololo) when used to treat eye disorders:

Development of a viral eye infection caused by the herpes simplex virus (HSV).
Generalised allergic reactions including swelling under the skin that may occur in areas such as the face and limbs and may block the airways causing difficulty in swallowing and breathing, urticaria or
itchy rash, localised and generalised rash, itching, sudden severe life-threatening allergic reaction.
Low blood sugar levels.
Dizziness.
Difficulty sleeping (insomnia), depression, nightmares, memory loss, hallucinations.
Fainting, heart attack, reduced blood supply to the brain, worsening of signs and symptoms of myasthenia gravis (a muscle disease), unusual sensations such as tingling, and headache.
Swelling at the back of the eye (macular oedema), fluid-filled cyst within the coloured part of the eye (iris cyst), light sensitivity (photophobia), sunken eyes (deepening of the eyelid groove).
Signs and symptoms of eye irritation (such as burning, stinging, itching, tearing, redness), eyelid inflammation, corneal inflammation, blurred vision, and detachment of the layer beneath the retina containing blood vessels following filtering surgery, which may cause visual disturbances, decreased corneal sensitivity, dry eyes, corneal erosion (damage to the front layer of the eyeball), drooping of the upper eyelid (causing the eye to be half-closed), double vision.
Darkening of the skin around the eyes, changes in eyelids and eyelid hair (increased number, length, thickness, pigmentation), changes in the direction of eyelash growth, swelling around the eye, swelling of the coloured part of the eye (iritis/uveitis), scarring of the eye surface.
Ringing or buzzing in the ears (tinnitus).
Angina, worsening of angina in patients already affected by heart disease.
Slow heartbeat, chest pain, palpitations (awareness of heartbeat), oedema (fluid accumulation), changes in heart rhythm or rate, congestive heart failure (heart disease associated with shortness of breath and swelling of feet and legs due to fluid accumulation), a type of heart rhythm disturbance, heart attack, heart failure.
Low blood pressure, poor blood circulation causing numbness and paleness of fingers and toes, cold hands and feet.
Shortness of breath, narrowing of the lung airways (mainly in patients with pre-existing lung disease), difficulty breathing, cough, asthma, worsening of asthma.
Taste disturbances, nausea, vomiting, indigestion, diarrhoea, dry mouth, abdominal pain.
Hair loss, skin rash with a silvery-white appearance (psoriasiform rash) or worsening of psoriasis, skin rash.
Joint pain, muscle pain not caused by physical exercise, muscle weakness, fatigue.
Sexual dysfunction, decreased libido.

In very rare cases, some patients with severe damage to the transparent layer at the front of the eye (the cornea) have developed cloudy spots on the cornea due to calcium deposits during treatment.

Reporting of side effects
If you experience any side effect, including those not listed in this leaflet, talk to your doctor or pharmacist. You can also report side effects directly via the national reporting system at: https://www.aifa.gov.it/content/segnalazioni-reazioni-avverse. By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Imolast

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date stated on the outer carton after "Exp." and on the bottle. The expiry date refers to the last day of the month.
Before opening, store the Imolast bottle in the refrigerator (2°C - 8°C). After first opening, it is not necessary to store the bottle in the refrigerator, but it must not be stored at temperatures above 25°C.
Use within 4 weeks of first opening. When not using Imolast, keep the bottle in the outer packaging to protect it from light.
Do not dispose of any medicine via wastewater or household waste. Ask your pharmacist how to dispose of medicines you no longer use. This will help protect the environment.

6. Contents of the pack and other information

What Imolast contains
In 1 ml of solution:

The active substances are: Latanoprost 50 micrograms and Timolol 5 milligrams (equivalent to timolol maleate 6.83 milligrams).
The other components are: sodium chloride, monosodium phosphate monohydrate, anhydrous disodium phosphate, benzalkonium chloride, water for injections.

Description of the appearance of Imolast and contents of the pack
Polyethylene bottle. Pack containing 1 bottle of 2.5 ml.
Marketing Authorisation Holder
Genetic S.p.A., Via Della Monica n. 26, 84083 Castel San Giorgio (SA)
Manufacturer
Genetic S.p.A., Contrada Canfora, 84084 Fisciano (SA)
This leaflet was last updated on