Diflucan 40 mg/ml powder for oral suspension: detailed information

Package leaflet: Information for the user

Introduction

Package leaflet: information for the user

Diflucan 10 mg/ml powder for oral suspension

Diflucan 40 mg/ml powder for oral suspension

fluconazole

Read the entire leaflet carefully before you start taking this medicine because it contains important information for you.

Keep this leaflet as you may need to read it again.
If you have any questions, ask your doctor, pharmacist or nurse.
This medicine has been prescribed for you only and must not be given to other people, even if they have the same symptoms as you, because it may harm them.
If you experience any adverse effects, consult your doctor, pharmacist or nurse, even if they are effects not listed in this leaflet. See section 4.

Leaflet contents:

What Diflucan is and what it is used for
What you need to know before taking Diflucan
How to take Diflucan
Possible side effects
How to store Diflucan
Contents of the pack and other information

1. What Diflucan is and what it is used for

Diflucan is one of the medicines belonging to the group called "antifungals". The active substance is fluconazole.

Diflucan is used to treat fungal infections, and it can also be used to prevent the occurrence of a Candida infection. The most common cause of fungal infections is a yeast called Candida.

Adults

Your doctor may prescribe this medicine to treat the following types of fungal infections:

Cryptococcal meningitis – a fungal infection of the brain.
Coccidioidomycosis – a disease affecting the bronchopulmonary system.
Infections caused by Candida located in the bloodstream, in body organs (e.g. heart, lungs), or in the urinary tract.
Mucosal candidiasis – infection affecting the lining of the mouth, throat, or associated with dental prostheses.
Genital candidiasis – infection of the vagina or penis.
Skin infections – e.g. athlete's foot, ringworm, jock itch, nail infections.

Diflucan may also be prescribed to:

prevent the recurrence of cryptococcal meningitis.
prevent the recurrence of mucosal Candida infections.
reduce the repeated occurrence of vaginal Candida infections.
prevent the transmission of Candida infections (if your immune system is weakened and not functioning properly).

Children and adolescents (0 to 17 years)

Your doctor may prescribe this medicine to treat the following types of fungal infections:

Mucosal candidiasis – infection affecting the lining of the mouth or throat.
Infections caused by Candida located in the bloodstream, in body organs (e.g. heart, lungs), or in the urinary tract.
Cryptococcal meningitis – a fungal infection of the brain.

Diflucan may also be prescribed to:

prevent the transmission of Candida infections (if your immune system is weakened and not functioning properly).
prevent the recurrence of cryptococcal meningitis.

2. What you need to know before taking Diflucan

Do not take Diflucan

if you are allergic (hypersensitive) to fluconazole, to other antifungal medications you have taken, or to any of the other ingredients of this medicine (listed in section 6). Symptoms may include itching, skin redness, or difficulty breathing.
if you are taking astemizole or terfenadine (antihistamines used to treat allergies).
if you are taking cisapride (used to treat stomach discomfort).
if you are taking pimozide (used to treat mental illnesses).
if you are taking quinidine (used to treat heart arrhythmias).
if you are taking erythromycin (an antibiotic used to treat infections).

Warnings and precautions

Talk to your doctor or pharmacist before starting Diflucan

if you have liver or kidney problems.
if you have a heart condition, including heart rhythm disorders.
if you have abnormal levels of potassium, calcium, or magnesium in your blood.
if severe skin reactions occur (such as itching, skin redness, or difficulty breathing).
if signs of “adrenal insufficiency” appear, in which the adrenal glands do not produce enough of certain hormones such as cortisol (chronic or prolonged fatigue, muscle weakness, loss of appetite, weight loss, abdominal pain).
if you have previously experienced a severe skin rash, skin peeling, blisters, and/or mouth sores after taking Diflucan.
Serious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS), have been reported with Diflucan treatment. Stop taking Diflucan and seek immediate medical attention if you notice any symptoms related to these serious skin reactions described in section 4.

Talk to your doctor or pharmacist if your fungal infection does not improve, as alternative antifungal treatment may be needed.

Taking Diflucan with other medicines

Tell your doctor or pharmacist if you are using, have recently used, or might need to use any other medicines.

Inform your doctor immediately if you are taking astemizole, terfenadine (an antihistamine for allergies), cisapride (used for stomach discomfort), pimozide (used to treat mental illnesses), quinidine (used to treat heart arrhythmias), or erythromycin (an antibiotic for infections), as these medicines must not be taken with Diflucan (see section: “Do not take Diflucan”).

Some medicines may interact with Diflucan. Make sure your doctor knows if you are taking any of the following medicines, as dose adjustment or monitoring may be needed to ensure these medicines remain effective:

Rifampicin or rifabutin (antibiotics for infections).
Alfentanil, fentanyl (used as anesthetics).
Abrocitinib (used to treat atopic dermatitis, also known as atopic eczema).
Amitriptyline, nortriptyline (used as antidepressants).
Amphotericin B, voriconazole (antifungals).
Medicines that reduce blood clotting (warfarin or similar medicines).
Benzodiazepines (midazolam, triazolam, or similar medicines) used to help sleep or for anxiety.
Carbamazepine, phenytoin (used to treat seizures).
Nifedipine, isradipine, amlodipine, verapamil, felodipine, and losartan (for high blood pressure).
Olaparib (used to treat ovarian cancer).
Cyclosporine, everolimus, sirolimus, or tacrolimus (to prevent transplant rejection).
Cyclophosphamide, vinca alkaloids (vincristine, vinblastine, or similar medicines) used to treat cancer.
Halofantrine (used to treat malaria).
Statins (atorvastatin, simvastatin, fluvastatin, or similar medicines) used to lower high cholesterol.
Methadone (used for pain).
Celecoxib, flurbiprofen, naproxen, ibuprofen, lornoxicam, meloxicam, diclofenac (Non-Steroidal Anti-Inflammatory Drugs -NSAIDs-).
Oral contraceptives.
Prednisone (a steroid).
Zidovudine, also known as AZT; saquinavir (used in HIV-infected patients).
Medicines for diabetes, such as chlorpropamide, glyburide, glipizide, or tolbutamide.
Theophylline (used to control asthma).
Tofacitinib (used to treat rheumatoid arthritis).
Tolvaptan (used to treat hyponatremia [low blood sodium levels] or to slow the decline in kidney function).
Vitamin A (nutritional supplement).
Ivacaftor (alone or combined with medicines used to treat cystic fibrosis).
Amiodarone (used to treat irregular heartbeats “arrhythmias”).
Hydrochlorothiazide (a diuretic).
Ibrutinib (used to treat blood cancer).
Lurasidone (used to treat schizophrenia).

Taking Diflucan with food and drinks

You may take this medicine with or without food.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

If you are planning to become pregnant, it is recommended that you wait one week after a single dose of fluconazole before trying to conceive.

For longer fluconazole treatment regimens, consult your doctor about the need to use appropriate contraceptive methods during treatment, which should be continued for one week after the last dose.

You must not take Diflucan if you are pregnant, think you may be pregnant, or plan to become pregnant, unless specifically instructed by your doctor. If you become pregnant while taking this medicine or within one week after the most recent dose, consult your doctor.

Fluconazole taken during the first or second trimester of pregnancy may increase the risk of miscarriage. Fluconazole use during the first trimester may increase the risk of congenital abnormalities affecting the baby’s heart, bones, and/or muscles.

Cases of babies born with congenital abnormalities affecting the skull, ears, and thigh and elbow bones have been reported in women treated for three months or more with high doses (400–800 mg daily) of fluconazole for coccidioidomycosis. The relationship between fluconazole and these cases is not clear.

Breastfeeding may continue after a single 150 mg dose of Diflucan. You must not continue breastfeeding if you are taking repeated doses of Diflucan.

Driving and using machines

Be aware that dizziness or seizures may occasionally occur, which could affect your ability to drive or operate machinery.

Diflucan oral suspension powder contains sucrose (sugar), sodium benzoate, and sodium (salt).

If your doctor has told you that you have an intolerance to certain sugars, consult with him before taking this medicine.

Patients with diabetes mellitus should be aware that this medicine contains 5.5 g or more of sucrose per 10 ml.

It may damage teeth if used for longer than 2 weeks.

The 60 ml bottle contains 83 mg of sodium benzoate per bottle, equivalent to 2.38 mg/ml.

Sodium benzoate may increase the risk of jaundice (yellowing of the skin and eyes) in newborns (up to 4 weeks of age).

After reconstitution, 1 ml of Diflucan 10 mg/ml oral suspension powder contains 1.13 mg of sodium per ml. This corresponds to 4.5% of the recommended maximum daily sodium intake for an adult.

After reconstitution, a 20 ml dose (maximum recommended dose) of Diflucan 40 mg/ml oral suspension powder contains less than 1 mmol of sodium (23 mg); this is essentially “sodium-free”.

3. How to take Diflucan

Follow exactly the administration instructions for this medicine as indicated by your doctor. If in doubt, consult your doctor or pharmacist again.

It is best to take your medication at the same time of day each day.

The recommended doses of this medicine for different types of infections are listed below:

Adults

Condition	Dosage
To treat cryptococcal meningitis	400 mg on the first day, followed by 200 mg to 400 mg once daily for 6 to 8 weeks or longer if necessary. The dose may occasionally be increased up to 800 mg
To prevent recurrence of cryptococcal meningitis	200 mg once daily until your doctor advises otherwise
To treat coccidioidomycosis	200 mg to 400 mg once daily for 11 to 24 months or longer if necessary. The dose may occasionally be increased up to 800 mg
To treat systemic fungal infections caused by Candida	800 mg on the first day, followed by 400 mg once daily until your doctor advises otherwise
To treat mucosal infections affecting the lining of the mouth, throat, or associated with dentures	200 mg to 400 mg on the first day, then 100 mg to 200 mg once daily until your doctor advises otherwise
To treat mucosal candidiasis – dosage depends on the site of infection	50 mg to 400 mg once daily for 7 to 30 days, or until your doctor advises otherwise
To prevent recurrence of mucosal infections affecting the lining of the mouth and throat	100 mg to 200 mg once daily, or 200 mg three times a week, for as long as the risk of developing an infection persists
To treat genital candidiasis	150 mg as a single dose
To reduce recurrent episodes of vaginal candidiasis	150 mg every third day for a total of 3 doses (day 1, 4, and 7), then once weekly for as long as the risk of infection persists
To treat fungal skin or nail infections	Depending on the site of infection: 50 mg once daily, 150 mg once weekly, or 300 to 400 mg once weekly for 1 to 4 weeks (for athlete’s foot, up to 6 weeks may be needed; for nail infections, continue treatment until a healthy nail has grown)
To prevent infection caused by Candida (if your immune system is weakened and not functioning properly)	200 mg to 400 mg once daily for as long as the risk of developing an infection persists

Adolescents aged 12 to 17 years

Follow the dose prescribed by your doctor (the adult or pediatric dosage).

Children up to 11 years of age

The maximum daily dose for children is 400 mg per day.

The dose will be based on the child's weight in kilograms.

Condition	Daily dose
Mucosal candidiasis and throat infections caused by Candida – the dose and duration of treatment depend on the severity of the infection and its location.	3 mg per kg of body weight once daily (on the first day, 6 mg per kg of body weight may be given)
Cryptococcal meningitis or internal fungal infections caused by Candida	6 mg to 12 mg per kg of body weight once daily
To prevent recurrence of cryptococcal meningitis	6 mg per kg of body weight once daily
To prevent a child from acquiring an infection caused by Candida (if their immune system is not functioning properly)	3 mg to 12 mg per kg of body weight once daily

Use in children from 0 to 4 weeks of age

Use in children from 3 to 4 weeks of age:

The same dose as described in the table, but administered once every 2 days. The maximum dose is 12 mg per kg of body weight every 48 hours.

Use in children under 2 weeks of age:

The same dose as described in the table, but administered once every 3 days. The maximum dose is 12 mg per kg of body weight every 72 hours.

Elderly patients

The usual adult dose, unless you have kidney problems.

Patients with kidney problems

Your doctor may adjust your dose depending on how well your kidneys are functioning.

Instructions for preparing the suspension:

It is recommended that your pharmacist reconstitute the oral suspension powder before giving it to you. However, if the pharmacist does not reconstitute this product, instructions are provided at the end of this leaflet in the section: “The following information is provided only for doctors and other healthcare professionals or for patients (in case the pharmacist does not reconstitute this product)”.

Instructions for use:

Shake the suspension bottle with the cap closed before each use.

Instructions for using the oral syringe:

Shake the prepared suspension well.
Open the bottle (safety cap);
Insert the oral syringe into the adapter in the neck of the bottle (Figure 1);
Turn the bottle upside down with the oral syringe pointing downward and withdraw the amount of suspension prescribed by your doctor (Figure 2). The markings on the syringe indicate milliliters (ml).

The maximum dose must not exceed 400 mg per day in children (see section 3 “How to take Diflucan”).

Turn the bottle upright with the oral syringe pointing upward and remove the syringe from the bottle.
The medicine may be administered directly into the mouth using the oral syringe. The patient should remain in an upright position during administration. Direct the oral syringe toward the inside of the cheek; slowly release the suspension into the patient’s mouth (Figure 3).
Rinse the oral syringe.
Close the bottle with the safety cap; the adapter should remain attached to the neck of the bottle.

Three sequential illustrations show how to aspirate liquid from a vial using a syringe and administer it orally to a child

For conversion of the oral suspension powder dose from mg/ml to ml/kg body weight in pediatric patients, see section 6.

In adult patients, calculate the dose in ml to be administered according to the recommended dosage in mg and the product concentration.

If you take more Diflucan than you should

Taking too much Diflucan may make you feel unwell. Contact your doctor immediately or go to the nearest hospital. You may also call the Toxicology Information Service at telephone number 91 562 04 20, indicating the medication and the amount ingested.

Symptoms of a possible overdose may include seeing, hearing, feeling, and thinking things that are not real (hallucinations and paranoid behavior). Symptomatic treatment may be appropriate (including supportive measures and gastric lavage if necessary).

If you forget to take Diflucan

Do not take a double dose to make up for a missed dose. If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose.

If you have any questions about how to use this medicine, ask your doctor or pharmacist.

4. Possible adverse effects

Like all medicines, this medicine can cause adverse effects, although not everyone experiences them.

Stop taking Diflucan and seek immediate medical attention if you notice any of the following symptoms:

widespread rash, high body temperature, and enlarged lymph nodes (DRESS syndrome or drug hypersensitivity syndrome).

Some people may develop allergic reactions, although severe allergic reactions are rare. If any adverse effect occurs, speak to your doctor or pharmacist. This includes any possible adverse effect not mentioned in this leaflet. If you experience any of the following symptoms, inform your doctor immediately:

sudden wheezing, difficulty breathing, or chest tightness.
swelling of the eyelids, face, or lips.
itching all over the body, skin redness, or itchy red spots.
skin rash.
severe skin reactions, such as blistering rash (this may affect the mouth and tongue).

Diflucan may affect your liver. Signs indicating liver problems include:

fatigue.
loss of appetite.
vomiting.
yellowing of the skin or whites of the eyes (jaundice).

If you experience any of these symptoms, stop taking Diflucan and contact your doctor immediately.

Other adverse effects:

Additionally, if you consider any of the adverse effects you experience to be severe, or if you notice any adverse effect not listed in this leaflet, inform your doctor or pharmacist.

Frequent adverse effects (may affect up to 1 in 10 patients) are:

headache.
stomach discomfort, diarrhoea, malaise, vomiting.
elevated blood test results indicating liver function abnormalities.
rash.

Uncommon adverse effects (may affect up to 1 in 100 patients) are:

reduction in red blood cells, which may cause pale skin, weakness, or difficulty breathing.
decreased appetite.
inability to sleep, numbness.
seizures, dizziness, spinning sensation, tingling, prickling, or numbness, changes in taste sensation.
constipation, indigestion, flatulence, dry mouth.
muscle pain.
liver damage and yellowing of the skin and eyes (jaundice).
hives, blisters (wheals), itching, increased sweating.
fatigue, general feeling of being unwell, fever.

Rare adverse effects (may affect up to 1 in 1,000 patients) are:

abnormally low levels of white blood cells, which help defend against infections, and blood cells that help stop bleeding.
red or purple skin discolouration, which may be due to low platelet count, other changes in blood cells.
changes in blood tests (high levels of cholesterol, fats).
low potassium levels in the blood.
tremors.
abnormal electrocardiogram (ECG), changes in heart rate or rhythm.
liver function failure.
allergic reactions (sometimes severe), including widespread blistering and peeling of the skin, severe allergic reactions, swelling of the lips or face.
hair loss.

Frequency not known, but possible (cannot be estimated from available data):

hypersensitivity reaction with skin rash, fever, swollen glands, increase in a type of white blood cells (eosinophilia), and inflammation of internal organs (liver, lungs, heart, kidneys, and colon) (drug reaction or rash with eosinophilia and systemic symptoms [DRESS]).

Reporting of adverse effects:

If you experience any type of adverse effect, consult your doctor, pharmacist, or nurse, even if it is a possible adverse effect not listed in this leaflet. You may also report them directly via the Spanish Pharmacovigilance System for Human Medicines: www.notificaRAM.es. By reporting adverse effects, you can help provide more information on the safety of this medicine.

5. Storage of Diflucan

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the vial and outer carton following EXP. The expiry date refers to the last day of the month indicated.

Powder prior to reconstitution: Store below 25°C. Keep the vial tightly closed.

After reconstitution: Store below 30°C. Do not freeze. The reconstituted suspension is stable for 28 days. Write the expiry date of the reconstituted suspension on the vial label.

Medicines must not be disposed of via wastewater or household waste. Any remaining suspension must be discarded 28 days after reconstitution. Return unused medicines and their containers to your local pharmacy’s SIGRE collection point. If you are unsure, ask your pharmacist how to dispose of medicines and containers you no longer need. This helps protect the environment.

6. Contents of the container and additional information

Composition of Diflucan

The active substance is fluconazole; 1 ml of reconstituted suspension contains 10 mg or 40 mg of fluconazole.
The other components (excipients) are sucrose, anhydrous colloidal silica, titanium dioxide (E 171), xanthan gum (E415), sodium citrate, anhydrous citric acid, sodium benzoate (E211), and natural orange flavour (containing orange essential oil and maltodextrin (containing glucose and maize starch)) (see section 2: Diflucan powder for oral suspension contains sucrose (sugar), glucose (sugar), sodium benzoate, and sodium (salt)).

Appearance of the product and contents of the container

Powder for oral suspension 10 mg/ml in a 60 ml bottle: 35 ml of suspension after reconstitution:

Diflucan 10 mg/ml powder for oral suspension is supplied in a 60 ml bottle containing 24.4 g of powder, which yields 35 ml of suspension after reconstitution.
Diflucan 10 mg/ml powder for oral suspension is a dry white or almost white powder. After adding water to the powder (following the instructions detailed later in the leaflet), a white or almost white suspension with an orange flavour is obtained.
In each bottle, mixing the powder with water produces 35 ml of suspension.
The 35 ml suspension is supplied with a 5 ml graduated oral syringe and a press-in bottle adapter to measure the correct dose.

Powder for oral suspension 40 mg/ml in a 60 ml bottle: 35 ml of suspension after reconstitution:

Diflucan 40 mg/ml powder for oral suspension is supplied in 60 ml bottles containing 24.4 g of powder, which yields 35 ml of suspension after reconstitution.
Diflucan 40 mg/ml powder for oral suspension is a dry white or almost white powder. After adding water to the powder (following the instructions detailed later in the leaflet), a white or almost white orange-flavoured suspension is obtained.
In each bottle, mixing the powder with water produces 35 ml of suspension.
It is supplied with a 5 ml graduated oral syringe and a press-in bottle adapter to measure the correct dose.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder:

Vinci Farma S.A. Avda de Europa, 20B. Parque Empresarial La Moraleja. 28108, Alcobendas (Madrid). Spain

Local representative:

Pfizer, S.L. Avda de Europa, 20B. Parque Empresarial La Moraleja. 28108, Alcobendas (Madrid). Spain

Manufacturer:

Fareva Amboise. Zone Industrielle. 29 Route des Industries. 37530, Pocé-sur-Cisse. France.

Date of the most recent revision of this leaflet: February 2024

Detailed and up-to-date information on this medicinal product is available on the website of the Spanish Agency of Medicines and Health Products (AEMPS): http://www.aemps.gob.es/

This information is intended for healthcare professionals and patients (in case the pharmacist does not reconstitute this product):

Instructions for preparing the suspension:

The reconstituted suspension will be a white or almost white suspension with an orange flavour.

Powder for oral suspension 10 mg/ml or 40 mg/ml in a 60 ml bottle: 35 ml of suspension after reconstitution:

Tap the bottle gently to loosen the powder.
Reconstitute by adding 24 ml of water. First, add a small amount of water and shake vigorously. Then, add water up to the fill line marked (?) on the bottle (in total, this corresponds to adding the required 24 ml of water).
Shake well for 1 to 2 minutes to obtain a homogeneous suspension.
After reconstitution, a usable volume of 35 ml will be obtained.
Write the expiry date of the reconstituted suspension on the bottle label (the shelf life of the reconstituted suspension is 28 days). Any remaining suspension must not be used after this date and should be returned to your pharmacist.

Conversion of oral suspension powder dosage from mg/ml to ml/kg body weight:

Diflucan and associated names 10 mg/ml powder for oral suspension:

In children, the dose of Diflucan powder for oral suspension should be measured as accurately as possible according to the following equation:

The oral syringe graduations are in 0.2 ml increments. Therefore, for intermediate weights and dosages, the dose to be administered in ml must be calculated and rounded up or down to the nearest syringe graduation.

For example, a child weighing 11 kg prescribed 3 mg/kg/day of Diflucan should receive 33 mg/day, equivalent to 3.3 ml of the 10 mg/ml oral suspension. The dose may be rounded to 3.4 ml, the nearest graduation on the oral syringe, to deliver the full dose.

The maximum dose should not exceed 400 mg per day in the paediatric population (see table *). The use of Diflucan 10 mg/ml powder for oral suspension is not recommended for doses > 15.0 ml (highlighted in grey in the table). If doses exceed 15.0 ml, Diflucan 40 mg/ml powder for oral suspension is recommended.

Dosage table with examples

	Dosage (corresponding dose in ml/day)
Weight in kg	3 mg/kg/day	6 mg/kg/day	12 mg/kg/day
3 kg	1.0 ml	1.8 ml	3.6 ml
5 kg	1.6 ml	3.0 ml	6.0 ml
7.5 kg	2.2 ml	4.6 ml	9.0 ml
10 kg	3.0 ml	6.0 ml	12.0 ml
12.5 kg	3.8 ml	7.6 ml	15.0 ml
15 kg	4.6 ml	9.0 ml	18.0 ml
20 kg	6.0 ml	12.0 ml	24.0 ml
25 kg	7.6 ml	15.0 ml	30.0 ml
30 kg	9.0 ml	18.0 ml	36.0 ml
35 kg	10.6 ml	21.0 ml	40.0 ml*
40 kg	12.0 ml	24.0 ml	40.0 ml*
45 kg	13.6 ml	27.0 ml	40.0 ml*

Diflucan and associated names 40 mg/ml powder for oral suspension:

In children, the dose of Diflucan powder for oral suspension should be measured as accurately as possible according to the following equation:

The increments on the oral syringe graduations are 0.2 ml. Therefore, for intermediate weights and dosages, the dose to be administered in ml must be calculated and rounded up or down to the nearest syringe graduation:

For example, a child weighing 23 kg who has been prescribed 6 mg/kg/day of Diflucan should receive 138 mg/day, equivalent to 3.45 ml of the 40 mg/ml oral suspension. The dose may be rounded to 3.4 ml, the nearest oral syringe graduation, to deliver the complete dose.

The maximum dose of 400 mg per day must not be exceeded in the pediatric population (see table *). The use of Diflucan 40 mg/ml powder for oral suspension is not recommended for weights below 15 kg. For weights below 15 kg, Diflucan 10 mg/ml powder for oral suspension is recommended.

Table with dosing examples

	Dosage (Corresponding dose in ml/day)
Weight in kg	3 mg/kg/day	6 mg/kg/day	12 mg/kg/day
15 kg	1.2 ml	2.2 ml	4.6 ml
20 kg	1.6 ml	3.0 ml	6.0 ml
25 kg	1.8 ml	3.8 ml	7.6 ml
30 kg	2.2 ml	4.6 ml	9.0 ml
35 kg	2.6 ml	5.2 ml	10.0 ml*
40 kg	3.0 ml	6.0 ml	10.0 ml*
50 kg	3.8 ml	7.6 ml	10.0 ml*