Capsici aquatica extract liquid

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT WATER PEPPER LIQUID EXTRACT (Extractum Polygoni hydropiperis)

Composition:

Active substance: polygonum hydropiper;

One vial contains 25 ml of liquid extract of water pepper herb (Herba Polygoni hydropiperis) (1:1), extraction solvent – 70% ethanol.

Dosage form. Liquid extract.

Main physicochemical characteristics: clear greenish-brown liquid with an aromatic odor.

Sediment may occur during storage.

Pharmacotherapeutic group.

Hemostatic agents of plant origin. ATC code B02BX.

Pharmacological Properties

Pharmacodynamics

The bioflavonoids present in water pepper (rutin, quercetin, hyperoside, ramnazin, kaempferol, myricetin, luteolin) exhibit P-vitamin activity, reduce capillary permeability, normalize vascular wall structure, and protect ascorbic acid present in water pepper from oxidation. Together with ascorbic acid, they participate in redox reactions and reduce hyaluronidase activity. The hemostatic effect of the drug is combined with the ability to stimulate uterine muscle contractions similar to ergot, although this property is considerably weaker.

The glycoside polygopiperin accelerates blood coagulation.

Tannins exert anti-inflammatory and astringent effects. Together with bioflavonoids, they produce a synergistic hemostatic effect.

The maximum pharmacological effect of water pepper bioflavonoids is achieved through extraction with 70% ethyl alcohol. At this concentration, flavonoids are dissolved in both free (aglycone) and bound (with the glycosidic moiety) forms. This ensures optimal absorption of the active substances through the microvilli of the gastrointestinal tract (GIT) into the bloodstream. Through redox reactions involving flavonoids, they undergo hydrolysis, forming aglycone and glycoside. The former is excreted by the kidneys in urine and via the intestine with bile, while the latter (the carbohydrate residue) is either oxidized in the Krebs cycle to carbon dioxide and water, or stored in the body as glycogen.

Pharmacokinetics. Not studied.

Clinical characteristics.

Indications.

As an adjunct in obstetric and gynecological practice for postpartum uterine bleeding, uterine subinvolution, and hypermenorrhea. Used for bleeding from small vessels of the stomach and intestine, as well as for mild hemorrhoidal bleeding.

Contraindications. Hypersensitivity to the components of the drug, children under 12 years of age.

Special precautions.

Do not administer with dairy products to prevent formation of non-absorbable complexes (chelates).

Interaction with other medicinal products and other forms of interaction. Not established.

Special precautions for use.

Use during pregnancy or breastfeeding.

Should be used only when the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Ability to affect reaction speed when driving or operating machinery.

Since the preparation contains ethanol, the use of «Water Pepper Liquid Extract» is not recommended while driving vehicles or operating potentially hazardous machinery.

Method of Administration and Dosage

"Pepper Tincture Liquid" should be taken by adults and children aged 12 years and older at a dose of 30–40 drops 3–4 times daily (half an hour before meals). The duration of treatment depends on the nature and severity of the disease, the therapeutic effect achieved, and the characteristics of combination therapy.

Children.

The efficacy and safety of the drug in children under 12 years of age have not been established; therefore, the drug is not recommended for use in this age group.

Overdose. In case of overdose, symptomatic treatment is administered.

Side effects.

Headache, nausea, vomiting, dizziness; allergic reactions, including skin rash, redness, itching.

Shelf life. 3.5 years.

Storage conditions. Store in original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.

Packaging. 25 ml in bottles.

Availability.

Over-the-counter.

Manufacturer. JSC «FITOFARM».

Manufacturer's address.

2 Sybitskova St., Bakhmut, Donetsk region, 84500, Ukraine.

Marketing Authorization Holder. JSC «FITOFARM».

Address of the Marketing Authorization Holder.

12 Almatinska St., Kyiv, 02092, Ukraine.