Oxygen medicinal liquid

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT MEDICAL GASEOUS OXYGEN

Composition:

Active substance: oxygen with a volume fraction of not less than 99.5%.

Pharmaceutical form. Gas.

Main physicochemical properties: colorless odorless and tasteless gas, supports combustion more actively than air, strong oxidizing agent.

Pharmacotherapeutic group. Medical gases.

ATC code V03A N01.

Pharmacological properties.

Pharmacodynamics.

Oxygen belongs to the group of drugs known as anti-hypoxants and antioxidants. It has the ability to bind with blood hemoglobin in the lungs and, as a complex compound with heme, is transported to the body's cells. Oxygen is a strong oxidizing agent and an essential element in the metabolic conversion of carbohydrates, proteins, and fats into energy required to sustain vital functions of the organism.

Pharmacokinetics.

In the human body, oxygen diffuses through lung tissue into the blood, where it binds to hemoglobin in erythrocytes and partially dissolves in plasma. Subsequently, oxygen is transported to body tissues, where it diffuses into the tissue interstitial fluid. The final stage of respiration is the utilization of oxygen in biological oxidation processes and the generation of cellular energy; following a series of transformations, oxygen is then excreted by the lungs in the form of carbon dioxide (CO₂).

Clinical characteristics.

Indications.

Diseases accompanied by hypoxia:

respiratory diseases:

• pneumonia;
• pulmonary edema;
• bronchial asthma;
• pneumosclerosis;

cardiovascular diseases:

• heart failure;
• coronary insufficiency.

Poisonings:

• carbon monoxide;
• hydrocyanic acid;
• suffocating gases.

Also used during general anesthesia in combination with inhalation anesthetics, and in the postoperative period.

For preparation of oxygen cocktails and foams.

Contraindications.

For hyperbaric oxygenation, contraindications include acute respiratory diseases, history of epileptic seizures, impaired patency of the auditory tubes and canals connecting the nasal sinuses with the external environment, presence of lung cavities, bronchopleural fistulas, severe forms of arterial hypertension, neoplasms, and increased individual sensitivity to oxygen.

Menstrual period, pregnancy over 5 months.

Interaction with other medicinal products and other types of interactions.

Nitrates, beta-blockers, calcium ion antagonists, and nootropic agents promote more efficient tissue oxygen utilization, improve oxygen utilization, and thus contribute to reduction of hypoxia and increased organism resistance to oxygen deficiency.

Special precautions for use.

The use of moisturizers is recommended.

Do not use during the menstrual period.

Use during pregnancy or breastfeeding.

Do not use during pregnancy for longer than 5 months.

Breastfeeding should be discontinued for the duration of treatment with this medicinal product.

Ability to affect reaction speed when driving or operating machinery.

Due to possible dizziness, it is advisable to avoid driving a vehicle or performing tasks that require increased attention and rapid reaction.

Administration and Dosage

In hospital settings, oxygen is most commonly administered via inhalation through special rubber or plastic masks connected directly to steel cylinders containing oxygen.

In outpatient practice and at home, special rubber or plastic containers (bags) filled with oxygen or its mixture are more frequently used.

For hyperbaric oxygenation, i.e., delivery of oxygen under increased pressure, special ventilated chambers, so-called hyperbaric chambers (barochambers), are used, where oxygen is administered both by inhalation and through mucous membranes and skin.

Oxygen is most commonly administered by inhalation as a mixture with air at a concentration of 40–60% at a flow rate of 4–5 liters per minute. A mixture called "carbogen," consisting of 95% oxygen and 5% carbon dioxide, is also used. Usually, the mixture is administered humidified.

During hyperbaric oxygenation, oxygen is delivered under pressure of 1.2–2 atm. For therapeutic purposes, 8–10 sessions are typically conducted.

Preparation of oxygen cocktails and foams: oxygen is mixed with food products, juices, herbal infusions.

Children.

The medicinal product is used in pediatric practice.

Overdose.

In case of overdose, nausea, vomiting, and convulsions may occur. Treatment is symptomatic.

Side effects.

In individual patients, individual increased sensitivity to oxygen and its mixtures, dizziness, nausea, increased dryness of mucous membranes, their irritation, cough may occur.

If any adverse reactions occur, consult a doctor.

Reporting of suspected adverse reactions: healthcare professionals should report any suspected adverse reactions through the national pharmacovigilance system.

Shelf life. 18 months.

Do not use the medicinal product after the expiry date stated on the packaging.

Storage conditions.

Store in a place protected from direct sunlight at a temperature not exceeding 50 °C. Avoid contact with open flame, heat sources, and oils. Do not drop.

Packaging.

Gas in 40 L steel cylinders.

Prescription status. Prescription only.

Manufacturer.

JSC "NAFTOKHIMIK PRYKARPATTYA".

Manufacturer's address and location of its business activity.

5 Maidanska Street, Nadvirna, Nadvirna District, Ivano-Frankivsk Oblast, 78400, Ukraine.