Oxygen medicinal gaseous

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT MEDICAL GASEOUS OXYGEN (OXYGEN MEDICAL GAS)

Composition:

active substance: oxygen;

oxygen not less than 99.5%.

Pharmaceutical form. Gas.

Main physico-chemical properties: colorless, odorless and tasteless gas. Slightly soluble in water (approximately 1:43).

Pharmacotherapeutic group.

Medical gases. ATC code V03A N01.

Pharmacological properties.

Pharmacodynamics.

Oxygen belongs to the group of anti-hypoxants and antioxidants. It has the ability to bind with blood hemoglobin in the lungs and, in a complex compound with heme, is transported to the body's cells. It is a strong oxidizing agent and an essential element in the metabolic transformations of carbohydrates, proteins, and fats into energy required to sustain vital functions of the body.

Pharmacokinetics.

In the human body, oxygen diffuses through the lung tissue into the blood, where it binds to hemoglobin in erythrocytes and partially dissolves in plasma. Subsequently, oxygen is transported to body tissues, where it diffuses into the tissue interstitial fluid. The final stage of respiration is the utilization of oxygen in biological oxidation processes and the generation of energy within cells; oxygen is then subsequently released from the body via the lungs in the form of carbon dioxide (CO₂) after a series of transformations.

Clinical characteristics.

Indications.

Conditions associated with hypoxia:

respiratory organs:

• pneumonia;
• pulmonary edema;
• bronchial asthma;
• pneumosclerosis;

cardiovascular system:

• heart failure;
• coronary insufficiency;

poisoning:

• carbon monoxide;
• cyanide;
• suffocating gases.

During general anesthesia, in combination with inhalation anesthetics; in the postoperative period.

Preparation of oxygen cocktails and foams.

Contraindications.

For hyperbaric oxygenation, contraindications include acute respiratory diseases, history of epileptic seizures, impaired patency of auditory tubes and canals connecting the paranasal sinuses, presence of lung cavities, bronchopleural fistulas, severe forms of arterial hypertension, neoplasms, and increased individual sensitivity to oxygen.

Interaction with other medicinal products and other types of interactions.

Nitrates, beta-blockers, calcium ion antagonists, and nootropic agents promote more efficient tissue utilization of oxygen, improve its utilization, and thereby reduce hypoxia and increase the body's resistance to oxygen deficiency.

Special precautions for use

Do not use in women during menstruation.

The use together with lubricants is recommended.

Use during pregnancy or breastfeeding

Do not use during pregnancy for longer than 5 months.

Breastfeeding should be discontinued for the duration of treatment with this medicinal product.

Ability to affect the speed of reactions when driving a vehicle or operating machinery

Due to the possible occurrence of dizziness, it is advisable to avoid driving a vehicle or performing tasks that require increased attention and quick reactions.

Method of Administration and Dosage.

In hospital settings, oxygen is most commonly administered via inhalation through special rubber or plastic masks connected directly to steel cylinders containing oxygen.

In outpatient practice and at home, special rubber or plastic containers (bags), filled with oxygen or its mixture, are more frequently used.

For hyperbaric oxygenation, i.e., oxygen delivery under increased pressure, special ventilated chambers, so-called hyperbaric chambers, are used, where oxygen is administered both by inhalation and through mucous membranes and skin.

Oxygen is most commonly administered by inhalation as a mixture with air at a concentration of 40–60% at a flow rate of 4–5 liters per minute. A mixture called "carbogen," consisting of 95% oxygen and 5% carbon dioxide, is also used. The mixture is usually administered humidified.

During hyperbaric oxygenation, oxygen is delivered under a pressure of 1.2–2 atm. Therapeutically, 8–10 sessions are typically conducted.

Preparation of oxygen cocktails and foams: oxygen is mixed with food products, juices, and herbal infusions.

Children.

The medicinal product is used in pediatric practice.

Overdose.

In case of overdose, nausea, vomiting, and convulsions may occur. Symptomatic therapy is administered.

Side effects.

In individual patients, individual hypersensitivity to oxygen and its mixtures, dizziness, nausea, increased dryness of mucous membranes, their irritation, cough may occur.

If any adverse events occur, it is necessary to consult a physician.

Shelf life. 18 months.

The medicinal product must not be used after the expiry date stated on the packaging.

Storage conditions.

Store in a place protected from direct sunlight, at a temperature not exceeding 50 °C.

Avoid contact with open flame and heat sources. Avoid contact with oils and lubricants. Do not drop.

Packaging.

Gas in steel cylinders of 1 L, 2 L, 10 L, and 40 L.

Prescription status. By prescription only.

Manufacturer.

JSC "Poltava Plant of Medical Glass".

Manufacturer's address and place of business.

158 Frunze Street, Poltava, Ukraine, 36008.