Curiosin

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT Curiosin

Composition:

Active substance: zinc hyaluronate;

1 g of gel contains zinc hyaluronate 1.027 mg;

Excipients: potassium sorbate, sodium hydroxide, carbomer, purified water.

Pharmaceutical form. Gel.

Main physicochemical properties: colorless or almost colorless transparent gel, practically odorless.

Pharmacotherapeutic group. Local treatment agents for acne.

ATC code D10AX.

Pharmacological properties.

Pharmacodynamics.

Hyaluronic acid and other proteoglycan molecules stabilize the intercellular substance of connective tissue. Zinc ions inhibit the activity of P. acnes lipase and also possess antibacterial properties. Curiosin gel reduces acne formation and the severity of the inflammatory process. Topical application of Curiosin gel supplements the increased demand for hyaluronic acid in tissues.

Hyaluronic acid, together with water molecules, forms a dispersion matrix that fills tissue defects, provides a natural support for cells, enhances granulocyte and macrophage activity, and stimulates fibroblast proliferation and angiogenesis. Zinc hyaluronate, compared to sodium hyaluronate, exhibits bacteriostatic activity against a range of microorganisms.

Pharmacokinetics.

Data on the pharmacokinetics of exogenous hyaluronic acid are insufficient.

According to scientific literature, the concentration of hyaluronic acid in healthy volunteers ranges from 10 to 100 mcg/L. Elevated plasma levels of hyaluronic acid have been observed in healthy (study) subjects of advanced age and in the morning in individuals with impaired liver function. Hyaluronic acid is rapidly eliminated from blood plasma; degradation into low-molecular-weight components occurs in the liver. After intravenous administration, the elimination half-life (t½) is 2.5–5.5 minutes. Hyaluronic acid is almost not excreted in urine (1%). Based on data from 22 healthy volunteers, the clearance of hyaluronic acid is 320 mcg over 24 hours.

Clinical characteristics.

Indications. Local treatment of all forms of mild to moderate acne, including comedones and papulopustular acne.

Contraindications.

Hypersensitivity to any ingredient of the medicinal product.

Interaction with other medicinal products and other forms of interaction.

Not known to date.

Special precautions for use.

The drug does not cause photosensitivity and does not stain skin or clothing.

Use during pregnancy or breastfeeding.

There are no data on the use of the medicinal product during pregnancy or breastfeeding.

Ability to influence reaction rate when driving or operating machinery.

The drug does not affect the ability to drive or operate machinery.

Dosage and Administration.

The medication is intended for external use.

Apply a thin layer to the affected area twice daily after hygienic cleansing of the skin.

The product is absorbed within a few minutes, therefore there is no need to apply a dressing.

Children.

There is no data available on the use of the medication in children under 14 years of age. The method of administration of Curiosin gel in children aged 14 years and older is the same as that for adults.

Overdose.

Not known to date.

Side effects.

At the beginning of treatment, skin burning sensation and redness may occur; these phenomena gradually disappear during therapy. Skin tightness and stretching sensation may occur in individuals with dry skin.

Allergic reactions are possible in individuals hypersensitive to the components of the drug.

From the skin and subcutaneous tissue.

Common (≥ 1/100 to < 1/10): skin burning sensation.

Shelf life. 2 years.

Storage conditions. Store at a temperature not exceeding 30 °C.

Keep the medication out of reach of children.

Packaging. 15 g of gel in a sealed aluminum tube with a white polyethylene cap equipped with a perforating tip. One tube per cardboard box.

Prescription category. Over-the-counter (without prescription).

Manufacturer. JSC "Gedeon Richter", Hungary.

Manufacturer's name and address of the place of business.

H-1103 Budapest, Dembowski Street 19-21, Hungary.