Altabor

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT ALTABOR (ALTABOR)

Composition:

Active ingredient: 1 tablet contains 20 mg of altabor, calculated as tannic acid and dry substance;

Excipients: sorbitol (E 420), citric acid monohydrate, pectin (citrus), apricot flavor, magnesium stearate, talc, sodium saccharin.

Pharmaceutical form. Tablets.

Main physicochemical properties: oval tablets ranging in color from light brown to dark brown with specks, biconvex surface, with an odor due to the presence of flavoring agent.

Pharmacotherapeutic group. Antiviral agents for systemic use. Direct-acting antiviral agents. Other antiviral agents. ATC Code J05AX.

Pharmacological Properties

Pharmacodynamics

The active ingredient of Altabor tablets is a dry extract substance derived from gray alder (Alnus incana) and sticky alder (Alnus glutinosa), containing a mixture of mono- and oligomeric ellagitannins based on phenolic acids (ellagic, gallic, and valoneic acid dilactone). These polyphenolic compounds exhibit antiviral activity against influenza virus, vesicular stomatitis virus, and herpes simplex virus. The antiviral mechanism of Altabor involves induction of interferon synthesis, inhibition of influenza virus neuraminidase activity, and suppression of herpesvirus-specific thymidine kinase, thereby halting viral DNA synthesis. Additional pharmacological properties of Altabor include antibacterial activity against Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella) microorganisms. The pharmacological profile of the drug is further characterized by antioxidant, anti-inflammatory, membrane-stabilizing, and analgesic effects, which enhance its therapeutic efficacy in the treatment of acute respiratory viral infections and influenza—conditions frequently complicated by bacterial infection and accompanied by inflammation and pain.

Pharmacokinetics

Not studied.

Clinical characteristics.

Indications.

Altabor is used for the prevention and treatment of influenza, acute respiratory viral infections.

Contraindications.

Altabor is contraindicated in case of hypersensitivity to the components of the drug, tannin-containing medicinal products.

Interaction with other medicinal products and other forms of interaction.

Due to its polyphenolic base, Altabor forms complexes with metal salts (such as aluminum, bismuth, iron), leading to loss of pharmacological activity of the drug.

Special precautions for use

The drug must not be administered concomitantly with almagel, bismuth preparations, iron, or other medicinal products containing metal ions.

The preparation contains sorbitol; therefore, it should not be used in patients with rare hereditary fructose intolerance.

If you have an intolerance to certain sugars, consult your doctor before taking this medicine.

The preparation contains sodium (sodium saccharin) in its composition, which should be taken into account by patients on a sodium-controlled diet.

Use during pregnancy or breastfeeding

There are no clinical data on the efficacy and safety of the drug in pregnant women; therefore, Altabor is contraindicated in this category of patients.

If it is necessary to use the drug in women who are breastfeeding, breastfeeding should be discontinued.

Ability to affect reaction speed when driving or operating machinery

Data are lacking.

Dosage and Administration.

For prophylaxis, take Altabor 2 tablets 3 times a day. The tablets should be slowly dissolved in the oral cavity. The duration of prophylaxis is 7 days.

For treatment, take Altabor 2 tablets 4 times a day. The tablets should be slowly dissolved in the oral cavity. The duration of treatment is 7 days.

Children.

There are no clinical data on the efficacy and safety of Altabor in children; therefore, Altabor should not be administered to children under 14 years of age.

Overdose.

In cases of hypersensitivity to the components of the drug, overdose may cause skin allergic reactions.

Treatment. Discontinue the drug immediately. Induce vomiting or perform gastric lavage. Symptomatic treatment is recommended.

Side effects.

When using Altabor, possible side effects include nausea, irritation of the soft palate, and allergic reactions such as rash, itching, skin hyperemia, and urticaria.

Shelf life.

2 years.

Do not use the medication after the expiry date.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 °C.

Keep out of reach of children.

Packaging.

10 tablets in a blister pack; 10 tablets in a blister pack, 2 blisters per carton; 20 or 60 tablets in a plastic container with a tamper-evident cap.

Availability.

Over-the-counter (without prescription).

Manufacturer.

Public Joint-Stock Company "Scientific-Production Center "Borshchahivskyy Chemical and Pharmaceutical Plant".

Manufacturer's address and place of business.

17 Miru Street, Kyiv, 03134, Ukraine.