Cardiolin

INSTRUCTION FOR MEDICAL USE OF THE MEDICINAL PRODUCT KARDIOLIN (CARDIOLIN)

Composition:

Active substance: tincture of medicinal plant raw materials: herb of Adonis vernalis (Herba Adonidis vernalis), fruits of common juniper (Fructus Juniperi communis), flowers of arnica (Arnicae flos), leaves of peppermint (Menthae piperitae folium);

1 bottle of drops contains tincture of medicinal plant raw materials (1:12.5): herb of Adonis vernalis (Herba Adonidis vernalis), fruits of common juniper (Fructus Juniperi communis), flowers of arnica (Arnicae flos), leaves of peppermint (Menthae piperitae folium) (extraction solvent – ethanol 40%) – 30 ml or 50 ml;

1 ml of the preparation contains 0.35 ml of ethanol.

Pharmaceutical form. Oral drops.

Main physicochemical properties: clear, light brown liquid with a pleasant odor.

Pharmacotherapeutic group.
Combined cardiovascular preparations. ATC code C01EX.

Pharmacological Properties

Pharmacodynamics

For functional cardiac disorders, the drug exerts cardioprotective and antioxidant effects.

Cardiolin is a combined preparation containing extracts from medicinal plants: herb of Adonis vernalis, which produces mild diuretic and sedative effects and possesses antiarrhythmic properties; fruits of common juniper (Juniperus communis), which have diuretic activity; flowers of arnica (Arnica montana), which exhibit cardioprotective activity; and leaves of peppermint (Mentha piperita), which demonstrate moderate spasmolytic, sedative, and choleretic effects.

The drug positively influences metabolic processes in the myocardium and liver, particularly by inhibiting lipid peroxidation, enhancing the activity of antioxidant enzymes, improving cellular energy balance, stimulating the synthesis of adenine nucleotides and glycogenolysis, and increasing the activity of certain enzymes in the Krebs cycle.

The drug exerts a mild sedative effect, reduces symptoms of diencephalic dysfunction, improves tolerance to physical exertion, and promotes increased work capacity.

Clinical characteristics.

Indications.

In the complex treatment of neurocirculatory dystonia, cardiac neuroses, and ischemic heart disease (exertional angina class I–II FC).

Contraindications.

Depression, history of alcoholism, concomitant use of alcohol-containing preparations, peptic ulcer disease of the stomach and duodenum, liver cirrhosis, concurrent use of neuroleptics and tranquilizers, increased sensitivity to the components of the drug, pronounced bradycardia, atrioventricular block, glycoside intoxication, WPW syndrome, severe kidney diseases.

Interaction with other medicinal products and other types of interactions.

Concomitant use with cardiac glycosides is undesirable, as the preparation contains Convallaria herb and glycoside toxicity manifestations are possible.

Since Cardiolin contains 40% ethyl alcohol and Convallaria herb, potentiation of the effects of sedatives, tranquilizers, sedative agents, and neuroleptics may occur. Additionally, the preparation may enhance the cardiotonic effect and toxicity of cardiac glycosides.

When used simultaneously with antiarrhythmic agents of class IA (quinidine, procainamide, disopyramide), calcium preparations, laxatives, and glucocorticosteroids, their effects and toxic actions may be enhanced.

Special precautions for use.

During treatment with the drug, consumption of alcoholic beverages should be avoided.

Patients with gastroesophageal reflux should not use the drug, as it may exacerbate heartburn.

Patients with cholelithiasis and other biliary tract disorders should use the drug with caution.

Use during pregnancy or breastfeeding.

Use is contraindicated.

Ability to affect reaction speed when driving or operating machinery.

During treatment with the drug, driving and operating potentially hazardous machinery are prohibited.

Dosage and Administration.

For adults, orally 20–30 drops 2–3 times daily, 30 minutes before or 1 hour after meals. The preparation may be diluted with water in a ratio of 1:3 or 1:5.

The duration of treatment is determined individually by a physician; the average duration is 20–30 days.

Children.

There is no experience with use in children.

Overdose.

With a significant overdose, somnolence, dyspeptic disorders, and allergic reactions are possible, requiring discontinuation of the drug and implementation of symptomatic therapy.

Side effects.

Cardiolin may cause hypersensitivity reactions, dyspeptic disorders, nausea, vomiting, abdominal pain, constipation, diarrhea, drowsiness, increased diuresis, sweating, chills.

Shelf life.

2 years.

Do not use the medicinal product after the expiry date stated on the packaging.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 °C. Keep out of reach of children. Sedimentation may occur during storage.

Packaging.

30 mL or 50 mL in a bottle. 1 bottle in a cardboard pack.

Availability.

Over-the-counter.

Manufacturer.

JSC "Biolyk".

Manufacturer's location and address of business activity.

131, Sh. Nezalezhnosti Str., Ladizhin, Vinnytsia region, 24321, Ukraine.

Marketing Authorization Holder.

LLC "Ukrainian Pharmaceutical Company".

Address of the Marketing Authorization Holder.

1U, Starosilska Str., Kyiv, 02660, Ukraine.